{"id":"W3042041751","doi":"10.1158/0008-5472.can-20-0788","title":"Plasma Gelsolin Inhibits CD8+ T-cell Function and Regulates Glutathione Production to Confer Chemoresistance in Ovarian Cancer","year":2020,"lang":"en","type":"article","venue":"Cancer Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Université du Québec à Montréal; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Ovarian cancer; Cancer research; Immunosurveillance; Microvesicles; CD8; Gelsolin; Biology; Cytotoxic T cell; Immune system; Cancer; Medicine; Immunology; Internal medicine; Cell biology; In vitro; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003820644,0.0001402369,0.0001368671,0.00007991969,0.00009916612,0.00004384997,0.0001593103,0.0001280596,0.00007465177],"category_scores_gemma":[0.0002176494,0.0001488405,0.00002842877,0.0004038832,0.0001385913,0.00001152051,0.0001875372,0.0002595819,0.00001790314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008450131,"about_ca_system_score_gemma":0.0002932786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001303602,"about_ca_topic_score_gemma":0.0004312944,"domain_scores_codex":[0.9982943,0.0001280459,0.0001957884,0.0006953575,0.0002978613,0.000388635],"domain_scores_gemma":[0.9991917,0.00001193582,0.00003826505,0.0002686945,0.0002197119,0.0002697122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001121812,0.00004091569,0.002379816,0.0001426746,0.00001503828,0.00000633631,0.00021131,0.0004651166,0.9874699,0.00005335147,0.005813997,0.002279756],"study_design_scores_gemma":[0.0008167955,0.0001505147,0.004046889,0.00006340098,0.000008467857,0.000001321888,0.0001282861,0.000127731,0.9859104,0.0001214005,0.008445098,0.0001796593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989319,0.004635021,0.0001338598,0.004975663,0.0001248787,0.0005465345,0.0000242764,0.00001303787,0.0002276992],"genre_scores_gemma":[0.9966393,0.0007204305,0.0001646904,0.0003615195,0.0006037161,0.0002787633,0.00002931863,0.00003657613,0.001165683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007320274,"threshold_uncertainty_score":0.606954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661197214953109,"score_gpt":0.3248031838206396,"score_spread":0.2881912116711085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}