{"id":"W3042076923","doi":"10.1016/j.molcel.2020.06.029","title":"Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; Carl Tryggers Stiftelse för Vetenskaplig Forskning; Ontario Genomics; National Institutes of Health; Vetenskapsrådet; Science Foundation Ireland; Government of Canada; Canadian Institutes of Health Research; LOEWE-Zentrum für Translationale Medizin und Pharmakologie; Ontario Research Foundation; Government of Ontario; Stanford University","keywords":"Biology; In silico; Phosphatase; Calcineurin; Cell biology; Interactome; Proteome; Computational biology; Nuclear transport; Ankyrin repeat; Biochemistry; Phosphorylation; Gene; Cell nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003971058,0.0004504879,0.0004204616,0.0002797268,0.0002567997,0.0007137739,0.0005014564,0.0005333422,0.001475613],"category_scores_gemma":[0.0008505438,0.0002985246,0.0003468349,0.0002900635,0.0003699545,0.0002707532,0.000488374,0.001561688,0.0007269927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006001822,"about_ca_system_score_gemma":0.0005705008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000689088,"about_ca_topic_score_gemma":0.001850912,"domain_scores_codex":[0.9997995,0.00004030704,0.0000152806,0.00003965406,0.00006603802,0.00003922955],"domain_scores_gemma":[0.9996093,0.0001342527,0.00009078121,0.00004591433,0.00005532002,0.00006448399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002590314,0.00004500427,0.0004701292,0.00005701891,0.00001834347,0.0001827195,0.00002444041,0.001057217,0.9899379,0.001859919,0.0001659374,0.005922423],"study_design_scores_gemma":[0.0000451396,0.000406708,0.0009829128,0.00001477696,0.00005189471,0.0002765663,0.00003832008,0.01060668,0.9805387,0.001028795,0.005986591,0.00002284782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9371401,0.00155567,0.05450517,0.0006527879,0.0002271661,0.0001685236,0.00106795,0.0008879862,0.003794675],"genre_scores_gemma":[0.9612575,0.001051603,0.0325668,0.0002581443,0.00003638764,0.00006095695,0.001362839,0.0002294776,0.003176239],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001475613,"threshold_uncertainty_score":0.004936397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257543828991818,"score_gpt":0.2365506918563448,"score_spread":0.2239752535664266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}