{"id":"W3042076923","doi":"10.1016/j.molcel.2020.06.029","title":"Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling","year":2020,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Institute of General Medical Sciences; Carl Tryggers Stiftelse för Vetenskaplig Forskning; Ontario Genomics; National Institutes of Health; Vetenskapsrådet; Science Foundation Ireland; Government of Canada; Canadian Institutes of Health Research; LOEWE-Zentrum für Translationale Medizin und Pharmakologie; Ontario Research Foundation; Government of Ontario; Stanford University","keywords":"Biology; In silico; Phosphatase; Calcineurin; Cell biology; Interactome; Proteome; Computational biology; Nuclear transport; Ankyrin repeat; Biochemistry; Phosphorylation; Gene; Cell nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572705,0.0002363469,0.0003320584,0.0000259735,0.00003494015,0.00002553402,0.0003618257,0.0001144436,0.00001117997],"category_scores_gemma":[0.0002763323,0.0002305412,0.000251646,0.0001392625,0.00006397926,0.000005902614,0.0001774747,0.00009549141,0.00001738106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009481693,"about_ca_system_score_gemma":0.00008013209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000669648,"about_ca_topic_score_gemma":4.658596e-7,"domain_scores_codex":[0.9984513,0.0001245821,0.0004526055,0.0004579885,0.0002627893,0.000250748],"domain_scores_gemma":[0.9990789,0.00002360261,0.0001234288,0.0005087572,0.00007931401,0.0001859749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007177637,0.00009740589,0.0004637477,0.003777988,0.00007798524,0.000108116,0.0000505362,0.004981191,0.9901739,0.00004010584,0.0001426204,0.00001466291],"study_design_scores_gemma":[0.0003398871,0.0001897686,0.00001091938,0.0002540818,0.0001317868,0.000002377793,0.00005699263,0.001304339,0.9973736,0.00001192278,0.00009030197,0.0002340655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468113,0.006837993,0.04540309,0.00004045999,0.00007417583,0.0004175507,0.0001101538,0.00002525694,0.0002799848],"genre_scores_gemma":[0.9975268,0.00002510447,0.001427538,0.0005948055,0.00009165127,0.00002814699,0.0001974454,0.00005579184,0.00005272044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05071547,"threshold_uncertainty_score":0.9401197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01257543828991818,"score_gpt":0.2365506918563448,"score_spread":0.2239752535664266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}