{"id":"W3042129498","doi":"10.1136/annrheumdis-2020-eular.2396","title":"THU0197 SAFETY PROFILE OF UPADACITINIB UP TO 3 YEARS OF EXPOSURE IN PATIENTS WITH RHEUMATOID ARTHRITIS","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Pfizer; Allergan; H. Lundbeck A/S; Eli Lilly and Company; Amgen","keywords":"Medicine; Adverse effect; Rheumatoid arthritis; Discontinuation; Internal medicine; Adalimumab; MedDRA; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007905234,0.0002109782,0.0009145866,0.0002764999,0.000213787,0.0007756848,0.0002618343,0.0004563185,0.003386811],"category_scores_gemma":[0.00181528,0.0001308121,0.0009700148,0.0003864722,0.0002098973,0.000515236,0.0002328593,0.001435722,0.0009278751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004483761,"about_ca_system_score_gemma":0.0005284494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009368414,"about_ca_topic_score_gemma":0.001690987,"domain_scores_codex":[0.9995254,0.0001317281,0.00004538522,0.00007238482,0.0001239107,0.0001011446],"domain_scores_gemma":[0.9991779,0.0002900645,0.0002192215,0.0000460042,0.0001478234,0.0001191079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1496135,0.002418122,0.1420051,0.002995706,0.004783794,0.002243687,0.000457297,0.006526383,0.03588274,0.001042997,0.0172634,0.6347672],"study_design_scores_gemma":[0.02708598,0.1371822,0.6654212,0.001823876,0.01362297,0.01387823,0.00135479,0.009019988,0.02302056,0.002203516,0.105037,0.0003495777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501415,0.03653882,0.0003855478,0.001085576,0.0002109855,0.00006678668,0.002784994,0.00007002055,0.008715778],"genre_scores_gemma":[0.99176,0.003917604,0.0001084678,0.0005092496,0.0001258035,0.00003255608,0.00177186,0.00001232382,0.001762265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003386811,"threshold_uncertainty_score":0.01133007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02056276654048842,"score_gpt":0.2662330432173505,"score_spread":0.2456702766768621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}