{"id":"W3042132061","doi":"10.1016/s1470-2045(20)30326-0","title":"Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22–05): a single-arm, phase 1b–2 trial","year":2020,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McMaster University; Juravinski Cancer Centre","funders":"Merck Sharp and Dohme; MacroGenics","keywords":"Pembrolizumab; Gastro-; Medicine; Internal medicine; Adenocarcinoma; Gastroenterology; Oncology; Cancer; Immunotherapy; Reflux; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001164741,0.001615035,0.001797433,0.0002831419,0.0002858726,0.001015706,0.0006852716,0.001263793,0.003869496],"category_scores_gemma":[0.0007114025,0.0005018571,0.001718788,0.0002939692,0.0006485138,0.001096272,0.0003421377,0.003183631,0.0009097895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009783286,"about_ca_system_score_gemma":0.0008360692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001343487,"about_ca_topic_score_gemma":0.005053739,"domain_scores_codex":[0.999733,0.0001061108,0.00001067898,0.00005866967,0.0000210922,0.0000703932],"domain_scores_gemma":[0.9997153,0.00004414668,0.00004917015,0.00002029846,0.00001511941,0.0001559563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8558791,0.01380265,0.003322471,0.00142496,0.00340712,0.0002476152,0.000221336,0.002795817,0.01274023,0.0003528631,0.006214049,0.09959178],"study_design_scores_gemma":[0.8636566,0.118499,0.01037822,0.0000739282,0.0009111975,0.0002250649,0.00007641975,0.00150261,0.001111558,0.0003129165,0.003217852,0.00003458768],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902759,0.004914972,0.0002358646,0.0008851266,0.0003563998,0.0006295767,0.000564323,0.00009554336,0.002042427],"genre_scores_gemma":[0.9864858,0.003587814,0.0008177532,0.001620001,0.0002691677,0.0007950373,0.001797964,0.00002756321,0.004598836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003869496,"threshold_uncertainty_score":0.01294476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07346060626970793,"score_gpt":0.3594422757535952,"score_spread":0.2859816694838873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}