{"id":"W3042137188","doi":"10.3390/ijms21144900","title":"Attenuation of Free Fatty Acid (FFA)-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol is Linked to Activation of AMPK and Inhibition of mTOR and p70 S6K","year":2020,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Brock University","funders":"Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children","keywords":"Internal medicine; Endocrinology; Insulin resistance; GLUT4; P70-S6 Kinase 1; Glucose uptake; Insulin; AMPK; Glucose transporter; Skeletal muscle; Chemistry; Resveratrol; AMP-activated protein kinase; Protein kinase B; Biology; Phosphorylation; Protein kinase A; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548193,0.0004312733,0.0005106725,0.0002738261,0.0001353059,0.0002026721,0.0002038617,0.0003106425,0.001136876],"category_scores_gemma":[0.00008250133,0.0002004625,0.0006221504,0.0002091173,0.0002013717,0.0002282077,0.0002141065,0.0006264712,0.0003429659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351223,"about_ca_system_score_gemma":0.0001604417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004425999,"about_ca_topic_score_gemma":0.0009423286,"domain_scores_codex":[0.9998516,0.00003658446,0.00002194745,0.00002434895,0.00002929877,0.00003617584],"domain_scores_gemma":[0.9999359,0.000008987293,0.00002284195,0.000007261202,0.000009859914,0.00001516019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003446902,0.00006344471,0.00009883048,0.00009021646,0.00001523745,0.00003090111,0.00001331112,0.00002725266,0.9982046,0.00003316252,0.0000410496,0.001037267],"study_design_scores_gemma":[0.00009249529,0.002360754,0.01527318,0.00002430844,0.00008946946,0.000311468,0.00006780537,0.0007725647,0.9783474,0.00005938567,0.002589298,0.00001186911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909917,0.004937323,0.001685512,0.0001995899,0.00008489182,0.00003435862,0.00029909,0.0001119478,0.001655556],"genre_scores_gemma":[0.9900293,0.004268334,0.002204343,0.0001629203,0.00003310033,0.00006246644,0.0007717001,0.00002301938,0.002444963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001136876,"threshold_uncertainty_score":0.003803194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01233026692917818,"score_gpt":0.2517616058329527,"score_spread":0.2394313389037745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}