{"id":"W3042166481","doi":"10.1139/cjpp-2020-0230","title":"The possible protective effect of colchicine against liver damage induced by renal ischemia–reperfusion injury: role of Nrf2 and NLRP3 inflammasome","year":2020,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Colchicine; Oxidative stress; Inflammasome; Pharmacology; Inflammation; Liver injury; Medicine; Reperfusion injury; Kidney; Reactive oxygen species; Renal ischemia; Renal function; Internal medicine; Ischemia; Endocrinology; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036778,0.0003994781,0.0004423382,0.0003387062,0.000215479,0.0002320446,0.0001667122,0.0003777412,0.001413343],"category_scores_gemma":[0.0001021198,0.0001072882,0.0003725036,0.0002172538,0.0002861641,0.0002890117,0.0001272141,0.0004165687,0.000129014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923682,"about_ca_system_score_gemma":0.0003845761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026144,"about_ca_topic_score_gemma":0.002873987,"domain_scores_codex":[0.9999232,0.00001597753,0.00001052089,0.00001261212,0.00001698044,0.00002071249],"domain_scores_gemma":[0.9999048,0.000009134721,0.00003803721,0.000005755134,0.00001753068,0.00002484117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002571155,0.0002204091,0.002280768,0.001505846,0.00009305584,0.0005893679,0.00005903335,0.0000837519,0.9791068,0.0002521658,0.0003561591,0.01288147],"study_design_scores_gemma":[0.0004294936,0.007706604,0.09999841,0.0001513868,0.0004982016,0.002130617,0.0003094377,0.0009463316,0.8756583,0.0003894003,0.01172731,0.00005456054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.932375,0.05993094,0.002394735,0.001033617,0.000260563,0.0001127948,0.0004826756,0.0001097643,0.003299901],"genre_scores_gemma":[0.9813637,0.0145495,0.001439847,0.000310608,0.00007260618,0.00005998039,0.0003098766,0.000006916204,0.001887059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413343,"threshold_uncertainty_score":0.004728138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003631163104917696,"score_gpt":0.2193828767273152,"score_spread":0.2157517136223975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}