{"id":"W3042192461","doi":"10.1101/2020.07.13.199976","title":"Insight into the autosomal-dominant inheritance pattern of SOD1-associated ALS from native mass spectrometry","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"SOD1; Amyotrophic lateral sclerosis; Mutant; Protein subunit; Mass spectrometry; Wild type; Mutation; Biology; Genetics; Molecular biology; Disease; Chemistry; Medicine; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004141503,0.0003024605,0.0002040846,0.0007015296,0.0001885168,0.0003418053,0.0001808525,0.0003081244,0.001603964],"category_scores_gemma":[0.0003013808,0.0001327067,0.0001323266,0.000306674,0.0001736325,0.0002020142,0.0002060377,0.0003388786,0.0006309926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001766336,"about_ca_system_score_gemma":0.0001084358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003275843,"about_ca_topic_score_gemma":0.0004730526,"domain_scores_codex":[0.9998727,0.00001995025,0.00001283893,0.00004296372,0.0000376827,0.00001382377],"domain_scores_gemma":[0.9998085,0.00004226057,0.00006091188,0.00002237995,0.00003058172,0.00003537993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006221029,0.00001344445,0.003106692,0.00003411793,0.00001087145,0.0001503498,0.0000323907,0.00004793276,0.9950359,0.0001228405,0.000130962,0.00125228],"study_design_scores_gemma":[0.00002697656,0.0001685212,0.1153404,0.00002764918,0.00006835136,0.006171558,0.0002259946,0.007331276,0.8642402,0.001330191,0.005044386,0.00002461121],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777132,0.003593349,0.0152028,0.0003605183,0.00004146373,0.00001859237,0.001016467,0.0002634255,0.001790304],"genre_scores_gemma":[0.9868938,0.0009300075,0.009649152,0.0001207868,0.00001908796,0.0000136215,0.0008206035,0.00005027741,0.001502751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603964,"threshold_uncertainty_score":0.005365789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02409278340706876,"score_gpt":0.2563005199035534,"score_spread":0.2322077364964846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}