{"id":"W3042194692","doi":"10.1016/j.exphem.2020.07.002","title":"Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies","year":2020,"lang":"en","type":"review","venue":"Experimental Hematology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Leukemia and Lymphoma Society","keywords":"Lineage (genetic); Haematopoiesis; Progenitor cell; Stem cell; Cell lineage; Biology; Tracing; Progenitor; Cell biology; Evolutionary biology; Genetics; Cellular differentiation; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001030243,0.0009506837,0.001453149,0.001593119,0.0002192304,0.00123235,0.001201643,0.001158608,0.002067318],"category_scores_gemma":[0.0009120887,0.000321945,0.0003788868,0.001768108,0.0009595449,0.001344151,0.0007615047,0.002628521,0.001403988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007604075,"about_ca_system_score_gemma":0.001216093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001017649,"about_ca_topic_score_gemma":0.001708425,"domain_scores_codex":[0.999795,0.00002972872,0.00002310845,0.00004429562,0.00008747485,0.00002035713],"domain_scores_gemma":[0.9994329,0.0003347126,0.00005583291,0.00001950035,0.0001082121,0.00004885211],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.000111172,0.00006360372,0.0001666212,0.01280789,0.00005452432,0.000132943,0.00004444734,0.0005053349,0.007155215,0.00822519,0.01947168,0.9512615],"study_design_scores_gemma":[0.00002546436,0.0001052929,0.0008195155,0.001957823,0.0001239215,0.0008461343,0.0000566823,0.0001573791,0.00304482,0.004173093,0.988658,0.00003193471],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009125129,0.9986695,0.0003319042,0.0001900966,0.0001373267,0.000002945451,0.00001811825,0.000008144727,0.0005507483],"genre_scores_gemma":[0.0004627578,0.9986385,0.0003159701,0.0001509325,0.000129638,0.000005159225,0.00002948891,0.000001740842,0.0002660071],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002067318,"threshold_uncertainty_score":0.006915927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04443182810117968,"score_gpt":0.3069758790812143,"score_spread":0.2625440509800346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}