{"id":"W3042194692","doi":"10.1016/j.exphem.2020.07.002","title":"Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies","year":2020,"lang":"en","type":"review","venue":"Experimental Hematology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Leukemia and Lymphoma Society","keywords":"Lineage (genetic); Haematopoiesis; Progenitor cell; Stem cell; Cell lineage; Biology; Tracing; Progenitor; Cell biology; Evolutionary biology; Genetics; Cellular differentiation; Gene; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007423252,0.0007109039,0.003310575,0.0002435896,0.00007684102,0.0000261322,0.0001873894,0.0007563333,0.00003556642],"category_scores_gemma":[0.000009969202,0.0005892633,0.0002325179,0.0002614264,0.0003697497,0.00006237276,0.000202371,0.0004838501,0.00003061345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379537,"about_ca_system_score_gemma":0.0001227772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001135658,"about_ca_topic_score_gemma":0.000001555612,"domain_scores_codex":[0.9968996,0.000194106,0.001388475,0.0008751374,0.0003028022,0.0003398833],"domain_scores_gemma":[0.998211,0.0004291983,0.0006207275,0.000491338,0.00004715983,0.0002005414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007559914,0.008988633,0.000246093,0.3885753,0.003191486,0.006675501,0.03970329,4.082334e-7,0.08517676,0.004665669,0.0008081355,0.4612127],"study_design_scores_gemma":[0.001252802,0.0006797211,3.279012e-7,0.01050946,0.0009030728,0.001127964,0.004881537,0.00001284182,0.8819118,0.00001039528,0.09828344,0.0004266633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00701418,0.9896075,0.000083,0.00006077273,0.0002742629,0.002355525,0.00008384215,0.0002223609,0.0002985344],"genre_scores_gemma":[0.05142274,0.9449843,0.002958179,0.00002815977,0.00006444428,0.0002485675,0.0001508844,0.0001114591,0.00003126184],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.796735,"threshold_uncertainty_score":0.9996559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04443182810117968,"score_gpt":0.3069758790812143,"score_spread":0.2625440509800346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}