{"id":"W3042196480","doi":"10.1136/annrheumdis-2020-eular.474","title":"OP0054 EFFICACY OF GUSELKUMAB, A MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO THE P19-SUBUNIT OF IL-23, ON ENDPOINTS RELATED TO AXIAL INVOLVEMENT IN PATIENTS WITH ACTIVE PSA WITH IMAGING-CONFIRMED SACROILIITIS: WEEK-24 RESULTS FROM TWO PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES","year":2020,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"Novartis Pharma; Celgene; Chugai Pharmaceutical; Pfizer","keywords":"Medicine; Sacroiliitis; BASDAI; Psoriatic arthritis; Axial spondyloarthritis; Internal medicine; Sacroiliac joint; Ankylosing spondylitis; Surgery; Nuclear medicine; Gastroenterology; Arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001298031,0.001429083,0.002916987,0.0005611497,0.0003923502,0.0008134856,0.0009969348,0.001867716,0.005387002],"category_scores_gemma":[0.001094931,0.0005269384,0.002008364,0.0004174958,0.001004198,0.0008364043,0.0002559203,0.002398391,0.0007747033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005009565,"about_ca_system_score_gemma":0.0008146197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009305913,"about_ca_topic_score_gemma":0.001802264,"domain_scores_codex":[0.9996247,0.0001598345,0.00003031768,0.00005357304,0.00003951856,0.00009203134],"domain_scores_gemma":[0.999441,0.0002066106,0.0001112711,0.00003560286,0.00003881316,0.0001666573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.913828,0.01308925,0.0008005041,0.002039555,0.001676199,0.00009950621,0.00007369133,0.0004595504,0.01642925,0.0001428553,0.001060391,0.05030117],"study_design_scores_gemma":[0.8703201,0.1211933,0.004774175,0.00006849798,0.000736355,0.00005625191,0.00003154075,0.0004062332,0.001710902,0.0000910247,0.0005864849,0.00002516211],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845585,0.009738687,0.0007046901,0.0004962527,0.0003378238,0.001155954,0.0008317584,0.0002229346,0.001953349],"genre_scores_gemma":[0.987467,0.00481824,0.0009965332,0.0009204673,0.0003768285,0.001041542,0.00135976,0.00002814766,0.002991486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005387002,"threshold_uncertainty_score":0.01802135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05550652916542601,"score_gpt":0.3145206718421891,"score_spread":0.2590141426767631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}