{"id":"W3042238380","doi":"10.15252/emmm.201911416","title":"Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers","year":2020,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; University College Dublin; Government of Canada","keywords":"Library science; Biological sciences; University hospital; Medicine; Family medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008820218,0.0001051257,0.0001980459,0.0001281659,0.00006683783,0.0001503592,0.00008727857,0.0001019931,0.0005918214],"category_scores_gemma":[0.0001157099,0.00006580268,0.00008608984,0.0001059252,0.0001232455,0.0001172609,0.0001129474,0.0002389863,0.00007699295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001922024,"about_ca_system_score_gemma":0.0001373969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000208815,"about_ca_topic_score_gemma":0.0005854671,"domain_scores_codex":[0.9999518,0.00001024276,0.000003066325,0.00001233739,0.00001054211,0.00001194509],"domain_scores_gemma":[0.999964,0.000006737668,0.00001092855,0.000005457267,0.000003599463,0.000009206447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002435245,0.00003906683,0.0004670856,0.0000237614,0.000002998074,0.0000160134,0.00000669554,0.0002888046,0.994895,0.0001100967,0.00006037917,0.003846517],"study_design_scores_gemma":[0.00005145936,0.002408432,0.01422957,0.000007138891,0.00001753798,0.0002395006,0.00002210784,0.002735744,0.9768385,0.0001292104,0.003314649,0.000006102643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959937,0.0007323258,0.002401163,0.00006813359,0.00001588629,0.0000244694,0.0001279183,0.00005599547,0.0005803325],"genre_scores_gemma":[0.9984102,0.000217573,0.0008715005,0.00002370249,0.000004669047,0.00001668767,0.0001054231,0.000006391588,0.0003438182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005918214,"threshold_uncertainty_score":0.001979828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591186277813689,"score_gpt":0.2675766697640085,"score_spread":0.2516648069858716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}