{"id":"W3042238380","doi":"10.15252/emmm.201911416","title":"Metronomic chemotherapy offsets HIFα induction upon maximum‐tolerated dose in metastatic cancers","year":2020,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; University College Dublin; Government of Canada","keywords":"Library science; Biological sciences; University hospital; Medicine; Family medicine; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002423987,0.0002846114,0.000442982,0.0001217079,0.0000390643,0.00001208423,0.0002092824,0.000127759,0.0001893357],"category_scores_gemma":[0.0001070526,0.0002655847,0.00009730805,0.0004000536,0.00009995028,0.00001035818,0.00004600396,0.0002157817,0.00001498567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000863937,"about_ca_system_score_gemma":0.0002361862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258288,"about_ca_topic_score_gemma":0.0001151087,"domain_scores_codex":[0.9983153,0.0001213504,0.0003965609,0.0005700201,0.0002432402,0.0003534693],"domain_scores_gemma":[0.9992176,0.000007344614,0.0001387285,0.0003377215,0.00007145161,0.0002271992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000319989,0.0000374553,0.00006993341,0.00003200774,0.0001322711,0.00001495297,0.0003411797,0.0006366977,0.9765316,0.00004649591,0.005568478,0.01626891],"study_design_scores_gemma":[0.01310713,0.001218187,0.005031816,0.0001068195,0.0002410421,0.00004935043,0.0007092551,0.001555866,0.5118142,0.0003252979,0.4649716,0.0008694108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768752,0.01137418,0.004046307,0.005235224,0.001053282,0.0004714067,0.00001281419,0.00003112814,0.0009004876],"genre_scores_gemma":[0.9898861,0.001552536,0.0005855063,0.006117363,0.001384331,0.00004963959,0.0002505842,0.00006009072,0.0001138256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4647174,"threshold_uncertainty_score":0.9999796,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01591186277813689,"score_gpt":0.2675766697640085,"score_spread":0.2516648069858716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}