{"id":"W3042240604","doi":"10.1002/ijc.33206","title":"Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer","year":2020,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"National Cancer Institute; National Institute on Aging; Cancer Council Victoria; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; National Institutes of Health; Vincent Fairfax Family Foundation; Haukeland Universitetssjukehus; Norges Forskningsråd; Universitetet i Bergen; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Karolinska Institutet; Cancer Council Queensland; Ministerio de Economía y Competitividad; Canadian Institutes of Health Research; Department of Defence, Australian Government; Cancerfonden; Hunter Medical Research Institute; Agency for Science, Technology and Research; National Heart, Lung, and Blood Institute; Fred C. and Katherine B. Andersen Foundation; Fred Hutchinson Cancer Research Center; Australian Government; Cancer Research UK; Wellcome Trust; Mayo Foundation for Medical Education and Research; U.S. Public Health Service; Genome Canada; Stockholms Läns Landsting; QIMR Berghofer Medical Research Institute; Susan G. Komen; Foundation for the National Institutes of Health; Kreftforeningen; Helse Vest; Cancer Council Tasmania; Brigham and Women's Hospital; European Commission; Breast Cancer Research Foundation; Ovarian Cancer Research Fund; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Endometrial cancer; Randomization; Biology; Medicine; Oncology; Mendelian inheritance; Cancer; Genetics; Internal medicine; Endocrinology; Bioinformatics; Gynecology; Clinical trial; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786995,0.00007600873,0.0001797476,0.00009700872,0.00001696175,0.00001995587,0.0003019639,0.0000407269,0.00003042882],"category_scores_gemma":[0.0001612473,0.00005379485,0.0001265546,0.0001011007,0.00002122293,0.0000102659,0.00002344759,0.00005970099,1.8477e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003412595,"about_ca_system_score_gemma":0.0003468459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006353106,"about_ca_topic_score_gemma":0.0005398036,"domain_scores_codex":[0.9990441,0.00004121798,0.0004483614,0.00009641382,0.0002875449,0.00008233065],"domain_scores_gemma":[0.9991429,0.00003173426,0.0003452785,0.00004777694,0.0003953517,0.00003688947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01069738,0.0001551434,0.00889853,0.00003515394,0.001340146,2.590106e-7,0.003730823,0.01554781,0.8141007,0.00007488734,0.009487997,0.1359311],"study_design_scores_gemma":[0.01881305,0.0001639799,0.008583253,0.00008481048,0.0001327207,0.000005801603,0.0005116299,0.0002381578,0.2537131,0.00003508589,0.7175686,0.000149845],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468638,0.01991929,0.01844259,0.004664364,0.009259476,0.0004902637,0.0001846362,0.000002763053,0.0001727802],"genre_scores_gemma":[0.985675,0.001667538,0.0006044387,0.0007469162,0.01120809,0.0000522011,0.00001863079,0.000008818619,0.00001839554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7080806,"threshold_uncertainty_score":0.219369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04001144290211562,"score_gpt":0.3726288245907705,"score_spread":0.3326173816886548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}