{"id":"W3042295407","doi":"10.1016/j.dmpk.2020.04.243","title":"P242 - In vitro functional characterization of rare genetic variants in hepatic bile acid and drug transporter NTCP","year":2020,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Transporter; In vitro; Bile acid; Drug; Chemistry; Pharmacology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002863341,0.0005294356,0.0003878592,0.0002640316,0.0002215923,0.000451948,0.0003529049,0.0004635077,0.002621912],"category_scores_gemma":[0.0007847527,0.000189725,0.0005328493,0.0003253974,0.0003002079,0.0001568819,0.0002280181,0.0007177165,0.001175632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003430036,"about_ca_system_score_gemma":0.0002329408,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002918336,"about_ca_topic_score_gemma":0.00175878,"domain_scores_codex":[0.9995504,0.0001490711,0.00006565734,0.00007930111,0.0001025139,0.00005312993],"domain_scores_gemma":[0.9996809,0.00014169,0.00005345417,0.0000461525,0.00004357438,0.00003415831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002532878,0.00005060487,0.0009896065,0.00003158794,0.00003568581,0.0006460926,0.00003615598,0.0003221377,0.9960423,0.000185788,0.0001153399,0.001291415],"study_design_scores_gemma":[0.00005491897,0.000342075,0.006103935,0.000007956698,0.00007265098,0.003975573,0.00007135757,0.003552361,0.9816395,0.0001007926,0.004063287,0.00001557803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991516,0.000563401,0.00464647,0.0002222667,0.00006801233,0.00004102336,0.00191859,0.00006033034,0.0009639533],"genre_scores_gemma":[0.9927109,0.0002065547,0.002173878,0.00006746098,0.00001901138,0.00003122014,0.002866105,0.00008291047,0.001841852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002918336,"threshold_uncertainty_score":0.008771181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217501853828773,"score_gpt":0.2265298615111291,"score_spread":0.2143548429728413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}