{"id":"W3042295407","doi":"10.1016/j.dmpk.2020.04.243","title":"P242 - In vitro functional characterization of rare genetic variants in hepatic bile acid and drug transporter NTCP","year":2020,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Transporter; In vitro; Bile acid; Drug; Chemistry; Pharmacology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403459,0.0002018455,0.000487707,0.000164697,0.0000248881,0.00001023623,0.00005772744,0.00006033943,0.0001648716],"category_scores_gemma":[0.000006565598,0.0001793639,0.00005228899,0.0003419163,0.00006544637,0.00009258636,0.00001359024,0.0002059774,0.000001850368],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006403334,"about_ca_system_score_gemma":0.00004458487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001805192,"about_ca_topic_score_gemma":0.000007402618,"domain_scores_codex":[0.9986893,0.00005448031,0.0004837697,0.0003142572,0.0002418766,0.0002163398],"domain_scores_gemma":[0.9995595,0.00001847202,0.00009255956,0.0001004694,0.00004609334,0.0001829438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000868319,0.0001560238,0.01592302,0.0005494587,0.00003446318,0.00009222289,0.003313953,0.00001552803,0.9711303,0.00003954686,0.00002778831,0.007849342],"study_design_scores_gemma":[0.005703967,0.00002396012,0.6884114,0.0001001584,0.0002999326,0.00001180432,0.0001380438,0.002584286,0.2979433,0.0000658435,0.004485878,0.0002314065],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946874,0.002449793,0.0008055283,0.001141566,0.0002396072,0.0004309904,0.0001646875,0.0000201858,0.00006020641],"genre_scores_gemma":[0.9943145,0.003548077,0.0007013771,0.0008667389,0.0001644756,0.00002100936,0.0002498945,0.000027489,0.0001064236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.673187,"threshold_uncertainty_score":0.7314246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01217501853828773,"score_gpt":0.2265298615111291,"score_spread":0.2143548429728413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}