{"id":"W3042337361","doi":"10.1093/hmg/ddaa154","title":"Regulation, diversity and function of MECP2 exon and 3′UTR isoforms","year":2020,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; University of Toronto; Ontario Brain Institute","keywords":"MECP2; Biology; Exon; Gene isoform; Untranslated region; Polyadenylation; Three prime untranslated region; Genetics; Alternative splicing; Rett syndrome; RNA-binding protein; Messenger RNA; DNA methylation; Molecular biology; Cell biology; Gene; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007163498,0.0003386091,0.0005348566,0.00007632098,0.0002432979,0.00001997611,0.0001726871,0.0002857595,0.000009437029],"category_scores_gemma":[0.00001485401,0.0003382244,0.0001506751,0.0001000194,0.0001416306,0.000001915753,0.001226899,0.0001156219,0.000001976442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009045464,"about_ca_system_score_gemma":0.00005251116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004163188,"about_ca_topic_score_gemma":0.000006888263,"domain_scores_codex":[0.9986596,0.00006871244,0.0003621495,0.0005498738,0.0001777844,0.0001818669],"domain_scores_gemma":[0.9992794,0.000004963106,0.0002309621,0.0003063737,0.00005946623,0.000118797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003519984,0.00009315486,0.0004292331,0.006549383,0.0006279114,0.0000145863,0.0002029307,0.00001280436,0.0750334,0.0004894724,0.0006209784,0.9158909],"study_design_scores_gemma":[0.0004947298,0.0006736492,0.01007286,0.0004329224,0.0007734993,0.00002664273,0.00002844398,0.000008672372,0.001622947,0.0006026057,0.9846025,0.000660528],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05087444,0.9478087,0.0006077146,0.000007510397,0.00006019848,0.0004125833,0.00002539511,0.000007663833,0.0001958271],"genre_scores_gemma":[0.05597399,0.9431748,0.0003516747,0.00006827289,0.00002305202,0.0000104616,0.0002674847,0.00005114857,0.00007907656],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9839815,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563614423472818,"score_gpt":0.2538542189221794,"score_spread":0.2282180746874512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}