{"id":"W3042337361","doi":"10.1093/hmg/ddaa154","title":"Regulation, diversity and function of MECP2 exon and 3′UTR isoforms","year":2020,"lang":"en","type":"review","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; University of Toronto; Ontario Brain Institute","keywords":"MECP2; Biology; Exon; Gene isoform; Untranslated region; Polyadenylation; Three prime untranslated region; Genetics; Alternative splicing; Rett syndrome; RNA-binding protein; Messenger RNA; DNA methylation; Molecular biology; Cell biology; Gene; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002229924,0.0001575307,0.0001944974,0.0002925185,0.0001474607,0.0004322442,0.0001585981,0.0002234662,0.0007123706],"category_scores_gemma":[0.000466958,0.0001503155,0.0002331596,0.0001757439,0.0001727744,0.000229194,0.0002060268,0.0002966402,0.0003651391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002270419,"about_ca_system_score_gemma":0.0001604513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008636325,"about_ca_topic_score_gemma":0.0008048889,"domain_scores_codex":[0.999747,0.00002862883,0.00002474049,0.0001044823,0.00005525266,0.00003987218],"domain_scores_gemma":[0.9996638,0.00009261924,0.00008741134,0.00003223864,0.00008833012,0.00003551351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001419042,0.000005981021,0.00524641,0.00004141812,0.00001238926,0.0001220291,0.00007251319,0.0001233367,0.9857959,0.0002474561,0.0001071208,0.008083523],"study_design_scores_gemma":[0.0000205868,0.0002233652,0.330393,0.00005279482,0.00008808351,0.003522012,0.0002366422,0.003270489,0.646233,0.0006904994,0.01523039,0.00003921881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9834695,0.009804006,0.00321564,0.00009630153,0.00002475918,0.000009986533,0.001121608,0.00007889145,0.002179328],"genre_scores_gemma":[0.9914373,0.002210388,0.002678281,0.00008966426,0.0000168987,0.00002179689,0.001143604,0.00004583823,0.002356309],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0008636325,"threshold_uncertainty_score":0.002383113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563614423472818,"score_gpt":0.2538542189221794,"score_spread":0.2282180746874512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}