{"id":"W3042350762","doi":"10.1128/aac.01450-20","title":"Safety, Tolerability, and Pharmacokinetics of a Novel Oral Amphotericin B Formulation (iCo-019) following Single-Dose Administration to Healthy Human Subjects: an Alternative Approach to Parenteral Amphotericin B Administration","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of British Columbia; iCo Therapeutics (Canada)","funders":"","keywords":"Tolerability; Pharmacokinetics; Amphotericin B; Pharmacology; Medicine; Oral administration; Toxicity; Adverse effect; Internal medicine; Antifungal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004164159,0.0002532549,0.0003498688,0.0001029121,0.0001392291,0.0003632905,0.0001127361,0.0003743794,0.0006322155],"category_scores_gemma":[0.0006126752,0.0001194632,0.0001732158,0.00008602846,0.0003150098,0.0002367158,0.00009352642,0.0006635566,0.0001598668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001257206,"about_ca_system_score_gemma":0.0002781033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005615852,"about_ca_topic_score_gemma":0.0004787112,"domain_scores_codex":[0.9997584,0.00009138617,0.00001374152,0.00005485992,0.00006097614,0.00002060361],"domain_scores_gemma":[0.9997135,0.00005810758,0.0001177263,0.00003285747,0.00003419534,0.00004358603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01650844,0.002882145,0.00851228,0.000176659,0.00008964979,0.0004153508,0.0002088364,0.0005951734,0.9098312,0.000116139,0.0003732285,0.06029083],"study_design_scores_gemma":[0.00211781,0.3375716,0.1092398,0.00004615771,0.0004483282,0.004401901,0.0003642045,0.005695436,0.5333474,0.0001412064,0.006552488,0.00007360705],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997539,0.0005893424,0.001253895,0.00004151315,0.00001917224,0.00008996316,0.00006495518,0.00001641607,0.00038561],"genre_scores_gemma":[0.9981823,0.0003403147,0.0007670302,0.00005809155,0.00002372003,0.00003782466,0.0001079612,0.000005573575,0.00047729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006322155,"threshold_uncertainty_score":0.002202213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07575954511087801,"score_gpt":0.3518994328016357,"score_spread":0.2761398876907576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}