{"id":"W3042375201","doi":"10.1101/2020.07.15.203125","title":"Modulation of Siglec-7 Signaling via <i>in situ</i> Created High-affinity <i>cis</i> -Ligands","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"SIGLEC; Glycan; Cell biology; Epitope; Chemistry; Immunological synapse; Immune system; Cytotoxicity; Biology; Effector; Antibody; T cell; Immunology; Glycoprotein; Biochemistry; T-cell receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125329,0.0003311596,0.0001539258,0.00008487512,0.0001231331,0.0003462759,0.000227922,0.0002496566,0.002131761],"category_scores_gemma":[0.00008769897,0.0001051625,0.0001430481,0.00008625946,0.0002439586,0.0001781053,0.0001995683,0.0004693971,0.0007225805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003050501,"about_ca_system_score_gemma":0.0001672792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003848294,"about_ca_topic_score_gemma":0.0003836369,"domain_scores_codex":[0.9998965,0.00002149599,0.000004940708,0.00001848807,0.00002664375,0.00003191027],"domain_scores_gemma":[0.9999621,0.000008553123,0.000009533857,0.000005347356,0.000005311053,0.000009141459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005161902,0.000010811,0.00003967881,0.00002141054,0.000002313265,0.00002423778,0.000006553459,0.00008394189,0.9989685,0.0002576937,0.00007134288,0.0004621095],"study_design_scores_gemma":[0.000003416118,0.00001803554,0.00008011687,7.875639e-7,0.000001458037,0.00002269861,0.000004178026,0.0003570247,0.9987038,0.00002488394,0.0007823589,0.000001294546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982924,0.0007565752,0.009221017,0.0002213748,0.0001181819,0.0000252434,0.0002606115,0.0001776714,0.006295289],"genre_scores_gemma":[0.9919807,0.0003991894,0.003373889,0.00009937435,0.00001362016,0.00001688893,0.0001863275,0.00005729372,0.003872763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002131761,"threshold_uncertainty_score":0.007131457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307003446480733,"score_gpt":0.2057347337483845,"score_spread":0.1926646992835772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}