{"id":"W3042412679","doi":"10.3390/vaccines8030393","title":"A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18–50 Years of Age","year":2020,"lang":"en","type":"article","venue":"Vaccines","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; NOSM University; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal; Pan-Provincial Vaccine Enterprise; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Reactogenicity; Adjuvant; Immunization; Seasonal influenza; Virology; Medicine; Virus; Influenza vaccine; Influenza A virus; Coronavirus disease 2019 (COVID-19); Immunology; Internal medicine; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000514523,0.000123604,0.000605347,0.00003336813,0.00003834854,0.000007626021,0.0001225804,0.0000314229,0.000003266271],"category_scores_gemma":[0.0002195034,0.00007974802,0.00008976019,0.0001869147,0.00001414553,0.000004110274,0.0000380147,0.00005073772,1.813624e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007241,"about_ca_system_score_gemma":0.0000705974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001814977,"about_ca_topic_score_gemma":0.0004959582,"domain_scores_codex":[0.9988213,0.0001781406,0.0005059615,0.0002195059,0.0001471818,0.0001279274],"domain_scores_gemma":[0.9993758,0.0001563198,0.0001490032,0.0001919532,0.00006128613,0.00006564616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5013865,0.0006527657,0.004240143,0.00001953138,0.0001597435,0.000001414963,0.0005981642,0.001010161,0.4917899,0.000005916822,0.000005437135,0.0001303798],"study_design_scores_gemma":[0.8300265,0.003991894,0.08487929,0.00009731154,0.0003423332,0.00000231332,0.000435983,0.006539939,0.07337604,0.000003043971,0.00009857171,0.0002067942],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961964,0.0003564639,0.0007118423,0.0004236048,0.00001384358,0.002200635,0.00008688801,0.000006936025,0.000003357208],"genre_scores_gemma":[0.9992923,0.00003840679,0.0001681591,0.000329758,0.00001306669,0.00009549037,0.00004992301,0.00001169712,0.000001193926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4184138,"threshold_uncertainty_score":0.325203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358361717530888,"score_gpt":0.2767996524845172,"score_spread":0.2532160353092083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}