{"id":"W3042412679","doi":"10.3390/vaccines8030393","title":"A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18–50 Years of Age","year":2020,"lang":"en","type":"article","venue":"Vaccines","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; NOSM University; Université Laval; Université de Montréal; Centre Hospitalier de l’Université de Montréal; Pan-Provincial Vaccine Enterprise; Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Reactogenicity; Adjuvant; Immunization; Seasonal influenza; Virology; Medicine; Virus; Influenza vaccine; Influenza A virus; Coronavirus disease 2019 (COVID-19); Immunology; Internal medicine; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002946788,0.001321704,0.0032756,0.0003473938,0.0005390694,0.0007866563,0.0006902757,0.002241064,0.004945235],"category_scores_gemma":[0.002284053,0.0005860628,0.001440349,0.000362004,0.001173335,0.0008726557,0.0004028881,0.002297745,0.0006533801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005525837,"about_ca_system_score_gemma":0.001170438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005405315,"about_ca_topic_score_gemma":0.001004199,"domain_scores_codex":[0.9987335,0.0006478649,0.0001089288,0.0002627743,0.0001031302,0.0001438565],"domain_scores_gemma":[0.9984961,0.0004959565,0.0003776533,0.000133514,0.0001471162,0.0003496228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9774204,0.01093144,0.0006052054,0.0007632005,0.0009061872,0.00003384336,0.00002983494,0.00008384567,0.002670073,0.0000713259,0.000297149,0.006187548],"study_design_scores_gemma":[0.7253016,0.2709587,0.001582846,0.00004042258,0.0006699714,0.0000265926,0.0000185432,0.00020484,0.0004602131,0.00009713051,0.0006294493,0.000009629631],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692535,0.005803002,0.001920496,0.0005986547,0.001320741,0.01848199,0.001024696,0.0001212481,0.001475616],"genre_scores_gemma":[0.9607314,0.002277558,0.004258782,0.001755997,0.0009023281,0.02578831,0.0007360614,0.00002336858,0.003526189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004945235,"threshold_uncertainty_score":0.01654351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02358361717530888,"score_gpt":0.2767996524845172,"score_spread":0.2532160353092083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}