{"id":"W3042451789","doi":"10.1016/j.dmpk.2020.04.122","title":"P121 - Early development of idiosyncratic drug-induced liver injury in an impaired immune checkpoint mouse model","year":2020,"lang":"en","type":"article","venue":"Drug Metabolism and Pharmacokinetics","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Liver injury; Immune checkpoint; Immune system; Drug; Drug development; Medicine; Neuroscience; Cancer research; Pharmacology; Immunology; Biology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003740471,0.001270576,0.0006109073,0.001090267,0.0002742462,0.0006284949,0.0005004172,0.001118402,0.002856847],"category_scores_gemma":[0.0003135931,0.0004131414,0.0007869772,0.00033757,0.0005944638,0.0008428788,0.0003739198,0.002592439,0.001151451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844518,"about_ca_system_score_gemma":0.0003718123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003029261,"about_ca_topic_score_gemma":0.0004187091,"domain_scores_codex":[0.9994951,0.00009901839,0.00004741205,0.0001147393,0.0001216626,0.0001219494],"domain_scores_gemma":[0.9994389,0.00006011414,0.0002034762,0.00008755251,0.0000367443,0.0001731308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002218275,0.0005796435,0.0006141685,0.00006078819,0.00001999509,0.0007354355,0.00003276819,0.0002703663,0.9916859,0.0005729618,0.0002035657,0.003006129],"study_design_scores_gemma":[0.0002007721,0.00317841,0.004014002,0.00001563305,0.00004713844,0.001723922,0.00004984489,0.001890641,0.9862093,0.000260938,0.002392737,0.00001657488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829445,0.00102709,0.01021831,0.0004062338,0.0001123624,0.0002155725,0.001449376,0.0005659638,0.003060549],"genre_scores_gemma":[0.9868622,0.0006126613,0.003251304,0.0001413947,0.00003684407,0.0002155307,0.0009817156,0.0001123338,0.007785933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002856847,"threshold_uncertainty_score":0.009557128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306858914905956,"score_gpt":0.2758957314032275,"score_spread":0.252827142254168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}