{"id":"W3042483363","doi":"10.1016/j.bmcl.2020.127414","title":"Intestinal anti-inflammatory activity of the total alkaloid fraction from Fumaria capreolata in the DSS model of colitis in mice","year":2020,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Center for International Business Education and Research, University of Illinois at Urbana-Champaign; Junta de Andalucía; European Commission; Instituto de Salud Carlos III; Canadian Thoracic Society","keywords":"Colitis; Inflammatory bowel disease; Chemistry; In vivo; Alkaloid; Inflammation; Pharmacology; Anti-inflammatory; Bone marrow; Immunology; Pathology; Biology; Medicine; Disease; Stereochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005955732,0.0003942267,0.0003401496,0.0004685372,0.0001778547,0.0001405145,0.0001449956,0.0002384062,0.001625899],"category_scores_gemma":[0.00006498396,0.0001082369,0.0002031544,0.0001530884,0.0001355797,0.0001959133,0.000107317,0.0003723206,0.0002577156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009028754,"about_ca_system_score_gemma":0.000144067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001000724,"about_ca_topic_score_gemma":0.001527141,"domain_scores_codex":[0.99997,0.000003817978,0.000002238697,0.000006396685,0.000007482456,0.00001010148],"domain_scores_gemma":[0.9999465,0.000008220616,0.00001007064,0.00000391441,0.00001071462,0.00002067453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007046227,0.00007449912,0.0001429613,0.0001096338,0.00001540629,0.00005423354,0.00001905033,0.00006485101,0.9961197,0.00003436573,0.00005295292,0.002607671],"study_design_scores_gemma":[0.0001578091,0.003029623,0.01580868,0.00003467463,0.0002149104,0.0003567392,0.00008303451,0.0008757627,0.9746171,0.00008766588,0.004714832,0.00001920636],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925161,0.003812539,0.001188979,0.0001518312,0.00004543969,0.00002626645,0.0006006881,0.00007057342,0.001587524],"genre_scores_gemma":[0.9932023,0.001728686,0.0009590447,0.0001029369,0.00002570122,0.00001746512,0.0007889119,0.00001301022,0.003162079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625899,"threshold_uncertainty_score":0.005439162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02528203714409034,"score_gpt":0.253119874004068,"score_spread":0.2278378368599777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}