{"id":"W3042490842","doi":"10.3390/genes11070808","title":"Intestinal Microbiota Influences DNA Methylome and Susceptibility to Colorectal Cancer","year":2020,"lang":"en","type":"letter","venue":"Genes","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Cancer Research Society","keywords":"Epigenetics; Colorectal cancer; DNA methylation; Inflammatory bowel disease; Biology; Reprogramming; Carcinogenesis; Mediator; Microbiome; Mouse model of colorectal and intestinal cancer; Intestinal epithelium; Gut flora; Cancer; Immunology; Cancer research; Disease; Bioinformatics; Genetics; Gene; Medicine; Gene expression; Epithelium; Cell biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005749848,0.0003189839,0.0004158993,0.0003524774,0.0005239859,0.0005042722,0.0002727775,0.004366675,0.003197663],"category_scores_gemma":[0.00230663,0.0001590089,0.0002541033,0.0002339903,0.0006084038,0.0003999879,0.0002998544,0.003211051,0.001842652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000612411,"about_ca_system_score_gemma":0.0003170922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00101418,"about_ca_topic_score_gemma":0.001503478,"domain_scores_codex":[0.9996911,0.0001104773,0.00001999218,0.00006334691,0.00007307522,0.00004196237],"domain_scores_gemma":[0.9992135,0.0004114668,0.00008521965,0.00004807275,0.0001405437,0.0001012645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.0037805,0.0003572582,0.0597838,0.0004992253,0.0002121424,0.0277964,0.0003449067,0.000392346,0.04281453,0.006990889,0.6640683,0.1929597],"study_design_scores_gemma":[0.0009146873,0.001258757,0.1208123,0.0003962196,0.0003051865,0.04820082,0.0006271584,0.003757428,0.01802148,0.02617203,0.7793626,0.0001714387],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.04513429,0.02614548,0.001101605,0.8897677,0.0208111,0.00005351183,0.000473304,0.0002324878,0.01628044],"genre_scores_gemma":[0.3252735,0.0249167,0.001372282,0.5474203,0.07594162,0.0001258722,0.0002780681,0.00008311273,0.02458852],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004366675,"threshold_uncertainty_score":0.01069725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781578458745006,"score_gpt":0.2786032954672816,"score_spread":0.2607875108798315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}