{"id":"W3042561762","doi":"10.1038/s41467-020-17415-x","title":"AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; University of Toronto; McGill University; Montreal Clinical Research Institute; Lunenfeld-Tanenbaum Research Institute; Université de Montréal","funders":"National Health and Medical Research Council; Medical Research Council; CIHR Skin Research Training Centre; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"GAS6; AXL receptor tyrosine kinase; Receptor tyrosine kinase; Focal adhesion; Paxillin; Phosphorylation; Cell biology; Metastasis; Cancer research; Signal transduction; Biology; Kinase; Cancer; JAK-STAT signaling pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007284496,0.0003052526,0.0001208597,0.0002206501,0.0001637725,0.000277491,0.0001230297,0.0001656048,0.00167658],"category_scores_gemma":[0.00003768206,0.0001162922,0.0001639517,0.00009834095,0.0001411849,0.0001546092,0.0002547535,0.0004107342,0.0003030138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004440713,"about_ca_system_score_gemma":0.0001974851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005526628,"about_ca_topic_score_gemma":0.001300313,"domain_scores_codex":[0.9999105,0.00001151133,0.000004003717,0.00001246888,0.00002860232,0.00003293671],"domain_scores_gemma":[0.9999582,0.000005028883,0.00001302591,0.000004719646,0.000003243159,0.00001592071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004978539,0.00001134924,0.0001535339,0.00001347086,0.000002061049,0.00003221918,0.000004481194,0.00004054459,0.9988481,0.0001235791,0.00005397915,0.0006670093],"study_design_scores_gemma":[0.000009082448,0.0001839489,0.007822447,0.000003005913,0.000006686894,0.0002992027,0.00001826815,0.001201502,0.9878072,0.00006598191,0.002579887,0.000002759433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957326,0.0009128879,0.001219044,0.0001336591,0.00001114386,0.000007880464,0.0002435926,0.00007707062,0.001662189],"genre_scores_gemma":[0.9949358,0.0004136312,0.001054816,0.00003999552,0.000005113824,0.00001154015,0.0005016737,0.000009665559,0.003027833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167658,"threshold_uncertainty_score":0.005608737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02011326051839291,"score_gpt":0.2452639600447916,"score_spread":0.2251506995263987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}