{"id":"W3042639872","doi":"10.1007/s10571-020-00923-1","title":"SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy","year":2020,"lang":"en","type":"article","venue":"Cellular and Molecular Neurobiology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Mitochondrial biogenesis; Diabetic neuropathy; Mitochondrion; Sirtuin 1; Chemistry; Neuroprotection; Resveratrol; Reactive oxygen species; Internal medicine; Endocrinology; Pharmacology; Streptozotocin; Oxidative phosphorylation; Oxidative stress; Neurite; Diabetes mellitus; Medicine; Downregulation and upregulation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003656186,0.0009081146,0.0008448766,0.0005004947,0.0003285767,0.0004140259,0.0005073799,0.000592497,0.002579406],"category_scores_gemma":[0.0001733373,0.0002982068,0.0006979749,0.0004160776,0.000542543,0.0006445211,0.0003569805,0.00176543,0.0002924655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003705546,"about_ca_system_score_gemma":0.0004739485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000979,"about_ca_topic_score_gemma":0.001885735,"domain_scores_codex":[0.9998171,0.00003150741,0.00002554304,0.00003716498,0.00002984297,0.00005899094],"domain_scores_gemma":[0.9998575,0.000009790209,0.00004071194,0.00002266609,0.00001735034,0.0000518236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01408754,0.0009935419,0.0007031694,0.0003983696,0.0001240745,0.000176298,0.00008411299,0.0003181674,0.9722688,0.0004300966,0.0003555305,0.0100604],"study_design_scores_gemma":[0.0009493349,0.007044649,0.01491795,0.0000616823,0.0004634669,0.0003213018,0.0003205532,0.002112797,0.9683393,0.0005483015,0.004878443,0.00004220395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930569,0.002436987,0.002447803,0.0002790352,0.0002538695,0.0000373914,0.0003310211,0.000178438,0.0009785951],"genre_scores_gemma":[0.9942247,0.001515071,0.001322441,0.0001354108,0.00003823296,0.00005212552,0.0004562529,0.00002676593,0.002229003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002579406,"threshold_uncertainty_score":0.008629024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008637599299165204,"score_gpt":0.2261809813509112,"score_spread":0.2175433820517459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}