{"id":"W3042694556","doi":"10.1136/rmdopen-2020-001217","title":"Impact of guselkumab, an interleukin-23 p19 subunit inhibitor, on enthesitis and dactylitis in patients with moderate to severe psoriatic arthritis: results from a randomised, placebo-controlled, phase II study","year":2020,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Dactylitis; Medicine; Enthesitis; Psoriatic arthritis; Placebo; Internal medicine; Psoriasis; Randomization; Arthritis; Placebo-controlled study; Randomized controlled trial; Dermatology; Pathology; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002298982,0.0003746061,0.001437807,0.0001296083,0.0001395247,0.00009935541,0.000182913,0.00006453101,0.0001015749],"category_scores_gemma":[0.0003222462,0.0002765421,0.00009691118,0.0002355169,0.00003622018,0.0002888041,0.0002373052,0.0001776535,0.00001623631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001434582,"about_ca_system_score_gemma":0.0001058768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003883595,"about_ca_topic_score_gemma":0.002310492,"domain_scores_codex":[0.9976584,0.0002370597,0.0007088342,0.0006748117,0.0003832059,0.0003377336],"domain_scores_gemma":[0.9986277,0.0002159612,0.0002199733,0.0004089633,0.0001339211,0.000393431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8960786,0.00693584,0.05188318,0.00001609815,0.00128963,0.0004346658,0.01809527,0.00007212308,0.00002868279,0.00000162185,0.0003671611,0.02479706],"study_design_scores_gemma":[0.83733,0.05959569,0.09999053,0.0007927451,0.0002579568,0.000005131068,0.001451989,0.0001621483,0.00009302665,0.0000111111,0.00002873993,0.0002808631],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896151,0.0001657638,0.000002474352,0.0002363907,0.00004976256,0.008326125,0.001065503,0.00002410609,0.0005147874],"genre_scores_gemma":[0.9987123,0.00006733595,0.0001317835,0.0002255738,0.00007198622,0.0003762917,0.0003076538,0.00004663523,0.0000604474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0587486,"threshold_uncertainty_score":0.9999686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964353732606064,"score_gpt":0.2961700253404053,"score_spread":0.2765264880143447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}