{"id":"W3042694556","doi":"10.1136/rmdopen-2020-001217","title":"Impact of guselkumab, an interleukin-23 p19 subunit inhibitor, on enthesitis and dactylitis in patients with moderate to severe psoriatic arthritis: results from a randomised, placebo-controlled, phase II study","year":2020,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Janssen Research and Development; Janssen Scientific Affairs","keywords":"Dactylitis; Medicine; Enthesitis; Psoriatic arthritis; Placebo; Internal medicine; Psoriasis; Randomization; Arthritis; Placebo-controlled study; Randomized controlled trial; Dermatology; Pathology; Double blind","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002153464,0.0009928553,0.002634941,0.0003496145,0.000323451,0.0007659055,0.0006674391,0.001312643,0.003900384],"category_scores_gemma":[0.001506162,0.0005772312,0.001579329,0.0003642741,0.0008299122,0.0006451277,0.0002666436,0.001797657,0.0005663076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004771722,"about_ca_system_score_gemma":0.0007535693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004928829,"about_ca_topic_score_gemma":0.000931268,"domain_scores_codex":[0.9992495,0.0004280083,0.00007175228,0.00009532522,0.000064486,0.00009102],"domain_scores_gemma":[0.998956,0.000312907,0.0002294518,0.00006305962,0.00006566724,0.0003730172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9443907,0.01110943,0.001160661,0.001234008,0.001137629,0.00008410404,0.00008407854,0.0002619694,0.01158862,0.00004889612,0.0004997884,0.02840011],"study_design_scores_gemma":[0.8487799,0.1446737,0.004833094,0.00003483059,0.000474219,0.00007123774,0.00001691325,0.0001301396,0.0004904197,0.00003855017,0.0004466214,0.00001032389],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987734,0.008741324,0.0003521684,0.0003482003,0.0002100254,0.001237324,0.0003245868,0.00004691263,0.001005414],"genre_scores_gemma":[0.9927207,0.003147171,0.0006532421,0.000692834,0.000247606,0.001092862,0.0004689741,0.00001048613,0.0009660832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003900384,"threshold_uncertainty_score":0.01304805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01964353732606064,"score_gpt":0.2961700253404053,"score_spread":0.2765264880143447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}