{"id":"W3042695800","doi":"10.1038/s41375-020-0962-2","title":"The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma","year":2020,"lang":"en","type":"article","venue":"Leukemia","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Vector Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; University of Pennsylvania; Terry Fox Research Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Mevalonate pathway; Geranylgeranylation; Bortezomib; Geranylgeranyl pyrophosphate; Statin; Cancer research; Apoptosis; Mevalonic acid; Proteasome inhibitor; Biology; Multiple myeloma; Carfilzomib; Medicine; Pharmacology; Prenylation; Internal medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001265677,0.0005048894,0.000354211,0.0004358424,0.0003266201,0.0003915351,0.0001843576,0.0004013691,0.00160839],"category_scores_gemma":[0.0001269642,0.0001847088,0.0004525787,0.0002739446,0.000301988,0.0002697285,0.0005288455,0.0004345804,0.0003148261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003660333,"about_ca_system_score_gemma":0.0002469269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005457732,"about_ca_topic_score_gemma":0.000662875,"domain_scores_codex":[0.9998017,0.00002798487,0.00002333282,0.00005060817,0.00004379354,0.0000526046],"domain_scores_gemma":[0.9999253,0.000005482192,0.00003578287,0.000007131991,0.00001122079,0.0000151778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003447006,0.00002144721,0.003646697,0.00006772704,0.00002280863,0.0003793537,0.00002698786,0.00005431961,0.9927463,0.0001137347,0.00007903435,0.002496869],"study_design_scores_gemma":[0.00007026118,0.001416737,0.1188995,0.00003433851,0.000182854,0.00994915,0.0002931602,0.001121122,0.8545451,0.0009541792,0.01249822,0.00003534653],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924945,0.003409641,0.002150281,0.0001752262,0.00003441279,0.00004049971,0.0004346093,0.00008796216,0.001172815],"genre_scores_gemma":[0.9965925,0.001115388,0.0008971212,0.00007830709,0.00001570597,0.00002239216,0.0003692058,0.00001019361,0.0008992057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160839,"threshold_uncertainty_score":0.00538063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426103935630866,"score_gpt":0.2471493586760767,"score_spread":0.232888319319768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}