{"id":"W3042695800","doi":"10.1038/s41375-020-0962-2","title":"The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma","year":2020,"lang":"en","type":"article","venue":"Leukemia","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Vector Institute; Princess Margaret Cancer Centre; Ontario Institute for Cancer Research; University of Toronto; University Health Network","funders":"National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; University of Pennsylvania; Terry Fox Research Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Mevalonate pathway; Geranylgeranylation; Bortezomib; Geranylgeranyl pyrophosphate; Statin; Cancer research; Apoptosis; Mevalonic acid; Proteasome inhibitor; Biology; Multiple myeloma; Carfilzomib; Medicine; Pharmacology; Prenylation; Internal medicine; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756216,0.0001268641,0.0001528258,0.000008710202,0.0001533363,0.00001964429,0.0002166721,0.000114728,0.00002785211],"category_scores_gemma":[0.0001603192,0.00009894965,0.0001113727,0.00008057907,0.000120396,0.000007746945,0.00008648392,0.0001224345,0.000009221076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004175236,"about_ca_system_score_gemma":0.0002754747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000190614,"about_ca_topic_score_gemma":0.0001308682,"domain_scores_codex":[0.9990351,0.00009058386,0.0001966498,0.0003292059,0.0001459703,0.0002025464],"domain_scores_gemma":[0.9992677,0.00002842692,0.0000896183,0.0003544929,0.0001426938,0.0001170762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004332989,0.00003271884,0.001161968,0.00002564409,0.00007463749,1.362663e-7,0.0006314871,0.0001357782,0.950527,0.0002273204,0.02362459,0.02312543],"study_design_scores_gemma":[0.0004991201,0.000132488,0.007482165,0.000002929018,0.00001291358,0.000001420855,0.0001476147,0.0003259492,0.4597698,0.00008063659,0.5314375,0.0001074424],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926456,0.001409745,0.0005155946,0.0007607994,0.002204365,0.0002653508,0.0001873078,0.00002068795,0.00199051],"genre_scores_gemma":[0.9933233,0.0003226194,0.0002181823,0.001188099,0.003966746,0.00002651736,0.00008135337,0.00001891069,0.0008542773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5078129,"threshold_uncertainty_score":0.403505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426103935630866,"score_gpt":0.2471493586760767,"score_spread":0.232888319319768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}