{"id":"W3042705185","doi":"10.3389/fncir.2020.00041","title":"Challenges for Therapeutic Applications of Opsin-Based Optogenetic Tools in Humans","year":2020,"lang":"en","type":"review","venue":"Frontiers in Neural Circuits","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Alberta","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"Optogenetics; Neuroscience; Neuromodulation; Computer science; Opsin; Biology; Stimulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005418554,0.000512016,0.0006793109,0.0004955527,0.0005871349,0.002515896,0.0007798407,0.001768546,0.006374497],"category_scores_gemma":[0.002753636,0.0002764899,0.0005565141,0.0001724166,0.002024521,0.002226186,0.001582257,0.003130251,0.002242321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009416179,"about_ca_system_score_gemma":0.00169044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006043625,"about_ca_topic_score_gemma":0.0007874603,"domain_scores_codex":[0.9986975,0.000509743,0.0001009133,0.0001501151,0.0004011698,0.0001405343],"domain_scores_gemma":[0.9983001,0.0009215489,0.0002336657,0.0001771443,0.000221851,0.0001457932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003429044,0.0002715366,0.00152497,0.0030238,0.0001343418,0.00118822,0.0005232606,0.003984692,0.1827494,0.1240754,0.03161851,0.6505629],"study_design_scores_gemma":[0.00007150606,0.001476832,0.002660742,0.00329798,0.0001205536,0.007855948,0.0009046462,0.003934348,0.04234794,0.06614482,0.8710945,0.00009012298],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03198026,0.5454375,0.2166473,0.1373725,0.004165987,0.0003870784,0.0003753612,0.00121678,0.06241727],"genre_scores_gemma":[0.273876,0.5008234,0.1755563,0.0293121,0.002450696,0.0009845314,0.000368481,0.0003455483,0.01628287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006374497,"threshold_uncertainty_score":0.02865642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2644360159859323,"score_gpt":0.4059030044380186,"score_spread":0.1414669884520863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}