{"id":"W3042708039","doi":"10.1158/1078-0432.ccr-20-1695","title":"Neoadjuvant and Adjuvant Pembrolizumab in Resectable Locally Advanced, Human Papillomavirus–Unrelated Head and Neck Cancer: A Multicenter, Phase II Trial","year":2020,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":365,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; National Human Genome Research Institute; National Institutes of Health","keywords":"Medicine; Head and neck cancer; Pembrolizumab; Adjuvant; Oncology; Head and neck; Human papillomavirus; Clinical trial; Cancer; Phases of clinical research; Internal medicine; Surgery; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001221132,0.0009682508,0.001155912,0.0001739096,0.0003096859,0.0006756232,0.0004674182,0.0008129746,0.001971117],"category_scores_gemma":[0.0004792669,0.0003886137,0.0008161154,0.0001958464,0.0005068446,0.0004441358,0.0002169981,0.001892862,0.0004610219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006796042,"about_ca_system_score_gemma":0.001111745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006682777,"about_ca_topic_score_gemma":0.00248229,"domain_scores_codex":[0.9997304,0.0001329941,0.00001850599,0.00004564779,0.00003008461,0.00004237879],"domain_scores_gemma":[0.9996502,0.00004326494,0.0000813891,0.00003217658,0.00002144842,0.0001714734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7978584,0.05586005,0.01068004,0.001149252,0.001788447,0.0001722919,0.0002380402,0.001424694,0.04593548,0.0001366765,0.002591706,0.08216487],"study_design_scores_gemma":[0.6431617,0.3250788,0.02199965,0.0000833018,0.0009196058,0.0002490226,0.00007076774,0.00118706,0.004455042,0.0001007311,0.002667,0.00002737459],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955108,0.002182889,0.0001905788,0.0002412703,0.00008536177,0.0009453586,0.0003003158,0.00003380768,0.0005097483],"genre_scores_gemma":[0.9931438,0.001922048,0.0007438663,0.0005107404,0.0001504949,0.001534944,0.0006483361,0.00001105127,0.001334731],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001971117,"threshold_uncertainty_score":0.006594062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.26414410117852,"score_gpt":0.5533957850436777,"score_spread":0.2892516838651577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}