{"id":"W3042720625","doi":"10.1080/19490976.2020.1785802","title":"Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production","year":2020,"lang":"en","type":"article","venue":"Gut Microbes","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Agriculture and Forestry; Albert and Margaret Alkek Foundation","keywords":"Cathelicidin; CXCL1; Biology; TLR4; Cell biology; Interleukin 8; TLR2; Secretion; Antimicrobial peptides; Signal transduction; Immunology; Innate immune system; Chemokine; Inflammation; Microbiology; Immune system; Antimicrobial; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002133411,0.0003268137,0.0004801924,0.0001474845,0.0002468915,0.00004013483,0.0002955285,0.0003129345,0.0005771323],"category_scores_gemma":[0.00008023228,0.0003180204,0.0001435894,0.0002327762,0.0002775525,0.0002013425,0.0001278478,0.0005580197,0.001683412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006415391,"about_ca_system_score_gemma":0.00007131537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005751854,"about_ca_topic_score_gemma":0.00008612181,"domain_scores_codex":[0.9981112,0.0001846809,0.0004929947,0.0005777704,0.00004262018,0.0005907186],"domain_scores_gemma":[0.9994246,0.00009099598,0.000192339,0.0001882877,0.00006479175,0.00003896551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002006851,0.0001697769,0.0002662214,0.00006397242,0.00008015683,0.00001668646,0.003001058,0.0001281118,0.991949,0.00004161313,0.003178373,0.0009044006],"study_design_scores_gemma":[0.0006568431,0.0001563148,0.0001089315,0.00004879191,0.00004483825,0.00003630741,0.0007309955,0.00002389908,0.9861483,0.00003690349,0.01165024,0.0003576396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940975,0.001664253,0.000310534,0.002455778,0.0007690206,0.0003965252,0.00009751035,0.0001632974,0.00004560933],"genre_scores_gemma":[0.9978158,0.0001855714,0.0001701845,0.0006318744,0.0002761557,0.00001716393,0.0001402171,0.00004575176,0.0007172967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008471866,"threshold_uncertainty_score":0.9999272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01181471538925426,"score_gpt":0.2031931621589831,"score_spread":0.1913784467697288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}