{"id":"W3042747985","doi":"10.1016/j.celrep.2020.107896","title":"Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Guelph; Western University; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Methylation; Proteome; Protein methylation; Computational biology; In silico; Human proteome project; Methyltransferase; Histone; Biology; Identification (biology); Proteomics; Bioinformatics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006512713,0.0005524408,0.0004022373,0.0006587831,0.000314141,0.0004869551,0.00021997,0.0003618232,0.001066808],"category_scores_gemma":[0.000694145,0.0002608931,0.0005014863,0.0005536859,0.000146061,0.0003000654,0.0003697007,0.0003893519,0.0006545952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000298175,"about_ca_system_score_gemma":0.0002971304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263176,"about_ca_topic_score_gemma":0.00242098,"domain_scores_codex":[0.9998165,0.00002850737,0.00001155314,0.00007504657,0.00005391948,0.00001457527],"domain_scores_gemma":[0.9997283,0.00007532983,0.00008340606,0.00003333128,0.00004831862,0.00003142489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005129714,0.0000596243,0.03655412,0.0001664961,0.0002008411,0.0001569177,0.00007931524,0.003891419,0.9403805,0.0002718759,0.0006411299,0.0170847],"study_design_scores_gemma":[0.00005447901,0.0003398847,0.1676602,0.00002582015,0.0002320618,0.0009079653,0.0001378429,0.1201414,0.7018258,0.001327135,0.007285357,0.00006203805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9238313,0.0009231014,0.06589188,0.0001612195,0.00002726673,0.00004723195,0.005981598,0.001529241,0.001607068],"genre_scores_gemma":[0.9387922,0.0003886441,0.05367702,0.00005603742,0.000006931126,0.00002682742,0.006289674,0.0001471003,0.0006155489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001263176,"threshold_uncertainty_score":0.003568828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01341697855213777,"score_gpt":0.2447572723148128,"score_spread":0.2313402937626751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}