{"id":"W3042767997","doi":"10.1128/aac.00899-20","title":"Antifungal Activity of Gepinacin Scaffold Glycosylphosphatidylinositol Anchor Biosynthesis Inhibitors with Improved Metabolic Stability","year":2020,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Glycomics Network; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Potency; Biosynthesis; Antifungal; Pharmacokinetics; In vitro; Metabolic stability; Biochemistry; Solubility; Pharmacology; Chemistry; Toxicity; Biological activity; Biology; Microbiology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349973,0.0003042792,0.0002456553,0.0002012715,0.0001126854,0.0003517958,0.0002401437,0.0002209924,0.001561968],"category_scores_gemma":[0.0002071389,0.00008357738,0.0001493494,0.0002117779,0.0001673699,0.0002624264,0.0002125432,0.0004696972,0.0002708908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003766165,"about_ca_system_score_gemma":0.0002659096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008550007,"about_ca_topic_score_gemma":0.001575843,"domain_scores_codex":[0.9999208,0.0000174669,0.000008821723,0.00001243963,0.00002066277,0.00001984778],"domain_scores_gemma":[0.9999536,0.00000862941,0.000009676352,0.000005324352,0.00001092249,0.00001177374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00042002,0.00007009432,0.0002042689,0.0000499791,0.00001022414,0.00009920941,0.00002145274,0.001148316,0.9905221,0.0001841061,0.000101644,0.007168557],"study_design_scores_gemma":[0.00006383556,0.00182275,0.001980978,0.000009349799,0.00002654931,0.0003023089,0.00002452828,0.002108058,0.9897048,0.00005058909,0.003895611,0.00001069464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926856,0.002211772,0.001473947,0.00009526988,0.00001595095,0.00003997645,0.0003012082,0.00006442983,0.003111807],"genre_scores_gemma":[0.99404,0.001297584,0.002237723,0.00004514109,0.000004052452,0.00002199924,0.0005893112,0.00001480942,0.001749403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001561968,"threshold_uncertainty_score":0.005225301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01860400125229963,"score_gpt":0.2439260366667461,"score_spread":0.2253220354144465,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}