{"id":"W3042768584","doi":"10.1101/2020.07.19.210955","title":"Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Institutes of Health","keywords":"Interferon; Gene isoform; Biology; Receptor; Virology; Interferon type I; Coronavirus; Virus; Primate; TMPRSS2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); In vitro; Coronavirus disease 2019 (COVID-19); Gene; Medicine; Genetics; Disease; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196648,0.0002304698,0.0001589012,0.0001187522,0.0001557661,0.0002775484,0.00006721764,0.0002029819,0.00195728],"category_scores_gemma":[0.0001474056,0.0001004263,0.0002365579,0.0000796446,0.0001633753,0.0001145248,0.0001489937,0.000428988,0.0005130023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074269,"about_ca_system_score_gemma":0.00009715838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001445149,"about_ca_topic_score_gemma":0.0002128214,"domain_scores_codex":[0.9998949,0.0000205794,0.000008442144,0.00002515652,0.00002255577,0.00002840268],"domain_scores_gemma":[0.999913,0.00001930192,0.00001673267,0.00001591547,0.00001294136,0.00002208287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499234,0.00001464934,0.0002647175,0.00001144381,0.000003269171,0.00005690614,0.000008526211,0.00002129459,0.9987436,0.0001001376,0.00004890505,0.0005766626],"study_design_scores_gemma":[0.00005091274,0.0003196518,0.00886901,0.000006202967,0.00001134396,0.0008317081,0.00004669241,0.001040046,0.9819709,0.0001335089,0.006716033,0.000003985281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925029,0.0009489662,0.002319846,0.000189069,0.0000837413,0.0000286622,0.0004482009,0.00004230508,0.003436303],"genre_scores_gemma":[0.9902601,0.0003385324,0.002443766,0.0001823974,0.00003411025,0.00002987414,0.001079179,0.00001891047,0.005613143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195728,"threshold_uncertainty_score":0.006547689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08548848463662487,"score_gpt":0.3181504735761044,"score_spread":0.2326619889394796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}