{"id":"W3042768584","doi":"10.1101/2020.07.19.210955","title":"Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; National Cancer Institute; National Institutes of Health","keywords":"Interferon; Gene isoform; Biology; Receptor; Virology; Interferon type I; Coronavirus; Virus; Primate; TMPRSS2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); In vitro; Coronavirus disease 2019 (COVID-19); Gene; Medicine; Genetics; Disease; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008626377,0.0008443332,0.001041521,0.000360254,0.0003147178,0.0005374553,0.0007300866,0.0007231553,0.00001200925],"category_scores_gemma":[0.0005701294,0.0006820275,0.0001815434,0.0006715921,0.0006418979,0.0002162502,0.001885521,0.002156869,0.0001277041],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003834916,"about_ca_system_score_gemma":0.001020469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001312654,"about_ca_topic_score_gemma":0.00001063295,"domain_scores_codex":[0.9959223,0.0001211784,0.0007281876,0.001608617,0.000765582,0.000854172],"domain_scores_gemma":[0.9971026,0.0002575325,0.0003471431,0.001615112,0.0004779324,0.0001996817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005347166,0.0001671389,0.005432964,0.0007828136,0.0002915981,0.00006330395,0.0001401234,7.423633e-8,0.9904298,0.0005458407,0.001589489,0.00002214605],"study_design_scores_gemma":[0.001349359,0.0002045024,0.01746794,0.0006171825,0.0001386766,3.959298e-7,0.000028785,0.0001124947,0.8084181,0.000002269486,0.171056,0.000604282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902164,0.00298758,0.0005167213,0.003091869,0.0006447553,0.00181148,0.0002911625,0.000392843,0.00004714415],"genre_scores_gemma":[0.9691181,0.0004340453,0.001928437,0.02723588,0.0007190296,0.0003407804,3.83658e-7,0.0002214777,0.000001848866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1820117,"threshold_uncertainty_score":0.9995631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08548848463662487,"score_gpt":0.3181504735761044,"score_spread":0.2326619889394796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}