{"id":"W3042795682","doi":"10.1021/acs.orglett.0c01847","title":"Total Synthesis of 6-Amino-2,6-dideoxy-α-Kdo from <scp>d</scp>-Mannose","year":2020,"lang":"en","type":"article","venue":"Organic Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Institut National de la Recherche Scientifique","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds De La Recherche Scientifique - FNRS; Réseau Québécois de Recherche sur les Médicaments","keywords":"Chemistry; Mannose; Stereochemistry; Stereoselectivity; Tandem; Total synthesis; Wittig reaction; Ring (chemistry); Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006590035,0.000332365,0.0005028989,0.00002752487,0.00007121536,0.00004764313,0.0004997154,0.000212912,0.003698519],"category_scores_gemma":[0.001319981,0.0003491871,0.0002484871,0.0002387846,0.0001336086,0.000122732,0.0001666776,0.0003009819,0.0002661578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008394075,"about_ca_system_score_gemma":0.00005452949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006982955,"about_ca_topic_score_gemma":0.000002152681,"domain_scores_codex":[0.9981742,0.00002893224,0.0004675368,0.0005675689,0.0003629909,0.0003987544],"domain_scores_gemma":[0.9978925,0.001012866,0.0002244366,0.0005763581,0.0000372082,0.0002566458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001296177,0.00005393124,0.0007902936,0.0001517918,0.0001770629,0.00008032691,0.0009033316,0.000007461206,0.9851523,0.00000471752,0.01214633,0.0005194883],"study_design_scores_gemma":[0.000278355,0.000006796784,0.0002795164,0.00006693795,0.000151147,0.000008784947,0.0007497253,0.00009388336,0.9957609,0.00001336302,0.002429946,0.0001606353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907163,0.0001118522,0.00005433446,0.003294809,0.00008223882,0.00004392338,0.0002390523,0.0001722781,0.005285147],"genre_scores_gemma":[0.9973705,0.00001675478,0.0001841933,0.001453011,0.0005994668,0.00001302041,0.00005126867,0.00007428403,0.000237533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01060861,"threshold_uncertainty_score":0.999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009726551035148561,"score_gpt":0.1834772363264412,"score_spread":0.1737506852912926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}