{"id":"W3042809965","doi":"10.1016/j.semarthrit.2020.06.020","title":"Discontinuation of biologic therapy due to lack/loss of response and adverse events is similar between TNFi and non-TNFi class: Results from a real-world rheumatoid arthritis cohort","year":2020,"lang":"en","type":"article","venue":"Seminars in Arthritis and Rheumatism","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University of Ottawa; University Health Network; McMaster University; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario Ministry of Health and Long-Term Care; Canadian Arthritis Network; Novartis; Amgen","keywords":"Medicine; Discontinuation; Rheumatoid arthritis; Adverse effect; Cohort; Arthritis; Internal medicine; Physical therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002494583,0.0004558279,0.0008486636,0.0007597129,0.0007815951,0.001972241,0.0008432536,0.0009967212,0.00356215],"category_scores_gemma":[0.007115399,0.0006608713,0.002056395,0.001111852,0.0006027619,0.001218491,0.0009986821,0.001472026,0.0006430957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005230193,"about_ca_system_score_gemma":0.0005902608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01141837,"about_ca_topic_score_gemma":0.01029536,"domain_scores_codex":[0.9970647,0.0007316609,0.0003209087,0.0009785505,0.0004119884,0.0004922977],"domain_scores_gemma":[0.995088,0.0008042532,0.002441119,0.0007453265,0.000409735,0.0005115373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001034441,0.0000753521,0.9965603,0.00002342718,0.0005418583,0.00007058815,0.0001328775,0.00003515998,0.0002009528,0.00002567484,0.0002473544,0.001051959],"study_design_scores_gemma":[0.00008447295,0.0002115667,0.9985751,0.00001012434,0.0001816761,0.0002196841,0.0002953346,0.0001113995,0.00003196136,0.0000292039,0.0002390983,0.00001039128],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968625,0.0004225242,0.000186679,0.00009390752,0.00002172878,0.00003031815,0.001741575,0.000008337015,0.0006324573],"genre_scores_gemma":[0.9978989,0.0001551728,0.0000854968,0.00007148521,0.00001949429,0.00002349598,0.001375814,0.00001092794,0.000359187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01141837,"threshold_uncertainty_score":0.02270383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02077292151421425,"score_gpt":0.2853054326451619,"score_spread":0.2645325111309477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}