{"id":"W3042813060","doi":"10.1101/2020.07.14.202317","title":"Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolution","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Dementias Platform UK; Great Ormond Street Hospital Charity; Stem Cell Network","keywords":"Biology; Neuroscience; Disease; Cell type; Reprogramming; Alzheimer's disease; Cerebral cortex; Cell; Pathology; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001857782,0.0004559547,0.0004410533,0.0002106123,0.0001676421,0.00008861748,0.0004018417,0.0002585848,0.00003346036],"category_scores_gemma":[0.0003558725,0.0005372154,0.0001554512,0.0003190559,0.000169153,0.0001321267,0.0007964088,0.0004153813,0.00006042155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006789958,"about_ca_system_score_gemma":0.0002016782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002669183,"about_ca_topic_score_gemma":2.532715e-7,"domain_scores_codex":[0.996752,0.0004857245,0.0005949133,0.001358451,0.0004379721,0.0003709685],"domain_scores_gemma":[0.9977868,0.00007088572,0.0005742694,0.000982504,0.0001408584,0.0004446961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006542219,0.0001061574,0.00006093078,0.0001581923,0.000008174623,0.000403324,0.000007475481,0.0003699797,0.9961184,0.002642833,0.00005867842,4.5797e-7],"study_design_scores_gemma":[0.0004074736,0.00008538281,0.0006070992,0.00003679252,0.0001406157,5.126341e-8,3.127699e-7,0.0030792,0.9944937,0.00001339656,0.0007033847,0.0004325441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934516,0.001128268,0.002942692,0.0005583857,0.0006462041,0.0007484269,0.0002272562,0.0002832632,0.00001392554],"genre_scores_gemma":[0.997633,0.000260143,0.00104919,0.0007640016,0.0001040798,0.00007139187,6.222414e-7,0.0001136903,0.000003822461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004181481,"threshold_uncertainty_score":0.9997079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425237091398734,"score_gpt":0.2197090470737979,"score_spread":0.1854566761598106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}