{"id":"W3042813060","doi":"10.1101/2020.07.14.202317","title":"Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolution","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Mental Health; Dementias Platform UK; Great Ormond Street Hospital Charity; Stem Cell Network","keywords":"Biology; Neuroscience; Disease; Cell type; Reprogramming; Alzheimer's disease; Cerebral cortex; Cell; Pathology; Genetics; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002838514,0.0001716581,0.000214737,0.0005470408,0.0002272688,0.0003878854,0.0001739299,0.0002914409,0.001187443],"category_scores_gemma":[0.0001466765,0.0001599292,0.0001334872,0.0002344468,0.0002505374,0.0001688267,0.0002984805,0.0002671446,0.0003310358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002471351,"about_ca_system_score_gemma":0.0001096572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008005896,"about_ca_topic_score_gemma":0.002044758,"domain_scores_codex":[0.9998814,0.00001229218,0.00001176019,0.00004687922,0.00002886229,0.00001878388],"domain_scores_gemma":[0.9998623,0.00003181338,0.00002857913,0.0000349337,0.00002524537,0.00001703328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007125147,0.000006280049,0.00307053,0.00002832348,0.00001399325,0.0001890965,0.00009144989,0.0001094815,0.9937705,0.0002403531,0.0001279537,0.002280765],"study_design_scores_gemma":[0.00002025266,0.0001477719,0.2619987,0.00002441756,0.0000745003,0.004339729,0.0004582456,0.003790196,0.7203671,0.002134538,0.006615337,0.00002932128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883744,0.001194195,0.00769755,0.00009148807,0.00002336768,0.000009321428,0.001210254,0.0001280421,0.001271463],"genre_scores_gemma":[0.9881743,0.0005965731,0.008639237,0.00007359521,0.00001324049,0.00002347536,0.0009923568,0.0000394939,0.001447594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001187443,"threshold_uncertainty_score":0.003972411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425237091398734,"score_gpt":0.2197090470737979,"score_spread":0.1854566761598106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}