{"id":"W3042987160","doi":"10.1111/jnc.15126","title":"Wild‐type and mutant SOD1 localizes to RNA‐rich structures in cells and mice but does not bind RNA","year":2020,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; SKiN Health; University of Ottawa","funders":"Institute of Genetics; Science and Engineering Research Council; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; ALS Society of Canada; Health Research","keywords":"SOD1; RNA; RNA-binding protein; RNA splicing; Stress granule; Molecular biology; Messenger RNA; Biology; Cell biology; Mutant; Gene; Chemistry; Genetics; Translation (biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002606627,0.0005529317,0.0002893713,0.0005594456,0.0001805187,0.0004346887,0.000339736,0.0006191402,0.001600106],"category_scores_gemma":[0.0001913437,0.0003958368,0.0002931768,0.0001958993,0.0005574041,0.0002942474,0.0002249972,0.0006047673,0.0008658156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003176947,"about_ca_system_score_gemma":0.0001961135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000385932,"about_ca_topic_score_gemma":0.0007100709,"domain_scores_codex":[0.9996504,0.00003749725,0.0000407851,0.0001438007,0.00009218233,0.00003537481],"domain_scores_gemma":[0.9996069,0.00006626925,0.000156609,0.00006183958,0.00002529765,0.00008313445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003647155,0.000006352594,0.0001787653,0.00001244971,0.00000402369,0.00003011302,0.00001107249,0.0000122445,0.9993269,0.00006921969,0.00001648608,0.0002958689],"study_design_scores_gemma":[0.00002430818,0.0002574636,0.01675999,0.00001681293,0.00002506845,0.0008940468,0.00004491227,0.0005238926,0.9780657,0.0002652053,0.003112545,0.00001014965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873961,0.002026149,0.007484118,0.0001996943,0.00006221479,0.0000202873,0.0008159471,0.0002229838,0.001772385],"genre_scores_gemma":[0.9851215,0.001106842,0.005976684,0.000179728,0.00002031827,0.00007932857,0.002141752,0.0001487916,0.005225024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001600106,"threshold_uncertainty_score":0.005352914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0229475677749413,"score_gpt":0.2782409800881044,"score_spread":0.2552934123131632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}