{"id":"W3042990191","doi":"10.1093/jncics/pkaa063","title":"Pilot Study Assessing Tolerability and Metabolic Effects of Metformin in Patients With Li-Fraumeni Syndrome","year":2020,"lang":"en","type":"article","venue":"JNCI Cancer Spectrum","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Center for Cancer Research","keywords":"Medicine; Metformin; Internal medicine; Endocrinology; Tolerability; Insulin; Lactic acidosis; Diabetes mellitus; Metabolic syndrome; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001161056,0.0005581884,0.0007398197,0.0002757901,0.0003973957,0.0003340116,0.0001837865,0.0003736992,0.001700503],"category_scores_gemma":[0.001287382,0.0001769158,0.0006479449,0.0002425113,0.0002561671,0.0003520852,0.000240513,0.0005726143,0.0002309115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00032198,"about_ca_system_score_gemma":0.000408504,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003688116,"about_ca_topic_score_gemma":0.0004745443,"domain_scores_codex":[0.9996436,0.0001673026,0.00003485252,0.00006841007,0.00004394395,0.00004190195],"domain_scores_gemma":[0.9988447,0.0002583308,0.000266865,0.00007580988,0.0001469009,0.0004073657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1627371,0.0343179,0.7057534,0.0003996108,0.001231803,0.002660063,0.0009898104,0.0008295896,0.03973856,0.00008597051,0.0006315908,0.05062466],"study_design_scores_gemma":[0.01031905,0.4848508,0.4961999,0.00002656574,0.0006771619,0.001240402,0.0004915082,0.001394212,0.003596956,0.00007041742,0.001094915,0.00003818489],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994722,0.00012456,0.00009087261,0.00001401959,0.00000556296,0.0001058076,0.00005821102,0.000003789979,0.0001250402],"genre_scores_gemma":[0.99923,0.00007116345,0.0002218422,0.00005687074,0.0000203996,0.0001323473,0.0001354724,0.000001535881,0.0001302946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700503,"threshold_uncertainty_score":0.006140292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009095058689008102,"score_gpt":0.2416063386260184,"score_spread":0.2325112799370103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}