{"id":"W3043009108","doi":"10.1080/23723556.2020.1789419","title":"Adding to the CASeload: unwarranted p53 signaling induced by Cas9","year":2020,"lang":"en","type":"article","venue":"Molecular & Cellular Oncology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Biology Research Center, Tel Aviv University; Azrieli Foundation; Tel Aviv University; Israel Cancer Association","keywords":"CRISPR; Palindrome; Cas9; Biology; P53 protein; Mutation; Genetics; Cancer research; Cell; Cell biology; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802362,0.000385322,0.0004394245,0.0001953099,0.0002974782,0.0007857198,0.0004422861,0.0007136124,0.003019713],"category_scores_gemma":[0.0004649628,0.0001848066,0.0003835766,0.000158771,0.0004423728,0.0005277374,0.000349417,0.001241406,0.0007126809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000294766,"about_ca_system_score_gemma":0.0002188973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000844277,"about_ca_topic_score_gemma":0.0007339868,"domain_scores_codex":[0.9995994,0.00003720685,0.00002850205,0.000131982,0.0001250871,0.00007781717],"domain_scores_gemma":[0.9996344,0.0001137187,0.00006759117,0.00008949295,0.00003710938,0.00005772685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000938933,0.00003340996,0.0001855906,0.00002330652,0.00000531892,0.0001963544,0.00001833164,0.000088403,0.997891,0.0002124625,0.00007252357,0.00117935],"study_design_scores_gemma":[0.000006176356,0.0001317729,0.0007918174,0.000002647038,0.000007563411,0.000226602,0.00002089612,0.0009037778,0.9963602,0.00009523705,0.00144888,0.000004283291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842336,0.0008814852,0.0106599,0.0004893569,0.0002275591,0.00006215378,0.000353887,0.0003465585,0.002745607],"genre_scores_gemma":[0.9926268,0.000270841,0.003711834,0.0001312901,0.00001809843,0.00002633482,0.000241893,0.00005716638,0.002915651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003019713,"threshold_uncertainty_score":0.01010197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01287473177902703,"score_gpt":0.2895312999988123,"score_spread":0.2766565682197852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}