{"id":"W3043012111","doi":"10.1039/d0fo00497a","title":"Pea protein-derived tripeptide LRW shows osteoblastic activity on MC3T3-E1 cells<i>via</i>the activation of the Akt/Runx2 pathway","year":2020,"lang":"en","type":"article","venue":"Food & Function","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"RUNX2; Chemistry; Bone resorption; Tripeptide; Osteoblast; RANKL; Protein kinase B; Phosphorylation; Signal transduction; Cell biology; Biochemistry; Endocrinology; Biology; Peptide; Activator (genetics); Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001050612,0.0003251248,0.0002351547,0.0001818518,0.0001084345,0.0001615325,0.0001088788,0.0002265547,0.001327812],"category_scores_gemma":[0.0000664856,0.00008163726,0.0004128884,0.0001257767,0.0001222394,0.0001272853,0.00009450577,0.000418497,0.0003379483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000115547,"about_ca_system_score_gemma":0.0001200568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000500802,"about_ca_topic_score_gemma":0.0009472864,"domain_scores_codex":[0.9999146,0.0000119822,0.00001035686,0.00001449396,0.00002956094,0.0000189416],"domain_scores_gemma":[0.9999596,0.000006761184,0.00001449116,0.000003695429,0.000005733607,0.000009663544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009460522,0.00002861308,0.00009011284,0.00003621775,0.000004676306,0.00004583989,0.000004320259,0.00001934225,0.9989769,0.00001405543,0.00002586599,0.0006595004],"study_design_scores_gemma":[0.00002569129,0.0008006389,0.005074346,0.000005399369,0.00002314891,0.0002793348,0.00002315942,0.0002158275,0.9917111,0.00001807873,0.001819561,0.000003647147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923862,0.003277999,0.001463606,0.0001534731,0.00003918984,0.00002172648,0.000545433,0.00005500447,0.002057364],"genre_scores_gemma":[0.9916912,0.001879769,0.002489339,0.0001345505,0.00002143517,0.00004051056,0.001222274,0.00002098272,0.00250002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327812,"threshold_uncertainty_score":0.004441977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242474347360407,"score_gpt":0.1853098148905896,"score_spread":0.1728850714169855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}