{"id":"W3043033743","doi":"10.1038/s41598-020-67496-3","title":"Long-term effects of medical management on growth and weight in individuals with urea cycle disorders","year":2020,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Child Health and Human Development; Sanofi Genzyme; Intellectual and Developmental Disabilities Research Center; Swedish Orphan Biovitrum; Deutsche Forschungsgemeinschaft; Universität Heidelberg; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Sanofi; European Commission; National Institutes of Health; Executive Agency for Health and Consumers; Rare Diseases Clinical Research Network; Danone; Vitaflo; Mead Johnson Nutrition; Kettering Fund","keywords":"Urea cycle; Term (time); Urea; Medicine; Weight management; Bioinformatics; Chemistry; Biology; Internal medicine; Biochemistry; Weight loss; Obesity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006293923,0.0002012402,0.0003061459,0.0002624262,0.000303497,0.0001996282,0.000128583,0.000225483,0.0004352798],"category_scores_gemma":[0.001904444,0.00007332018,0.0003426864,0.0002254022,0.0002815209,0.0002001459,0.0002954314,0.0002922347,0.00005565209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979746,"about_ca_system_score_gemma":0.0002590026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00209658,"about_ca_topic_score_gemma":0.004094839,"domain_scores_codex":[0.9997355,0.0001218636,0.00002258914,0.00002996824,0.00004647631,0.00004355051],"domain_scores_gemma":[0.9990087,0.0003294973,0.0003183031,0.0000626669,0.0000695526,0.0002112126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009483371,0.001153004,0.908571,0.0001042658,0.0003959096,0.0007623115,0.0002375422,0.0003592311,0.006952791,0.00007663874,0.0001902278,0.07171375],"study_design_scores_gemma":[0.0000504633,0.004435502,0.9937758,0.0000159534,0.0001162074,0.000365605,0.0001004959,0.0001607685,0.0007327785,0.00005576431,0.0001849658,0.000005776331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998431,0.001165511,0.00005146706,0.00005334499,0.000004855054,0.000003055,0.0000454145,0.000003275624,0.0002419471],"genre_scores_gemma":[0.9991888,0.0004336328,0.0001099885,0.00002442162,0.000007316619,0.000003735268,0.0000944747,0.000001126788,0.0001364872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00209658,"threshold_uncertainty_score":0.004168808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003273496669219159,"score_gpt":0.2180842727765888,"score_spread":0.2148107761073697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}