{"id":"W3043048574","doi":"10.1016/j.celrep.2020.107908","title":"Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models","year":2020,"lang":"en","type":"review","venue":"Cell Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":330,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Division of Mathematical Sciences; National Institute of Neurological Disorders and Stroke; National Institute on Aging; Alzheimer's Disease Research Center, University of Pittsburgh; School of Medicine, Johns Hopkins University; National Institutes of Health; Icahn School of Medicine at Mount Sinai; Huffington Foundation; Translational Genomics Research Institute; Johns Hopkins Hospital; CurePSP; Veterans Administration Medical Center; JPB Foundation; Texas Children's Hospital; Mayo Clinic; Cancer Prevention and Research Institute of Texas; Cullen Foundation; Rush University; Illinois Department of Public Health; Michael J. Fox Foundation for Parkinson's Research; Emory University; Houston Endowment; Adrienne Helis Malvin Medical Research Foundation; Mayo Foundation for Medical Education and Research; Johns Hopkins University; Arizona Biomedical Research Commission; Boler Family Foundation; Arizona Department of Health Services; Burroughs Wellcome Fund; National Science Foundation","keywords":"Transcriptome; Disease; Neuroscience; Computational biology; Human brain; Biology; Bioinformatics; Medicine; Gene; Genetics; Gene expression; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002726089,0.0003994749,0.002720471,0.0004358647,0.00008817101,0.00002215871,0.00007186396,0.0001357352,0.0002838679],"category_scores_gemma":[0.00003516277,0.0002352519,0.003214724,0.0009518221,0.0001205939,0.00008739627,0.000061249,0.000334976,0.000002484276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007949422,"about_ca_system_score_gemma":0.0005484615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000867869,"about_ca_topic_score_gemma":0.00002647062,"domain_scores_codex":[0.997131,0.0002448582,0.0009486756,0.0006999259,0.0007261673,0.000249395],"domain_scores_gemma":[0.9980918,0.00008789777,0.0004842833,0.0007406882,0.00008062858,0.0005147519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.00009613448,0.001085715,0.0008092992,0.005128482,0.9828082,0.003417632,0.00008997077,0.00007299141,0.00001330997,0.00004658363,0.0004166809,0.006015011],"study_design_scores_gemma":[0.0002652318,0.0000540826,0.0009532095,0.0002035652,0.9782406,0.00006723118,0.000009853688,0.00008892767,0.00001082866,0.0001534118,0.01974078,0.0002122651],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005716076,0.99721,0.00001166121,0.0001216056,0.00004063554,0.001434444,0.0001870121,0.00002232081,0.0004007311],"genre_scores_gemma":[0.1271517,0.8703672,0.00001025982,0.00005856213,0.00004750947,0.0003983391,0.001151834,0.00006674886,0.0007477843],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1268427,"threshold_uncertainty_score":0.9593295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2081488139692128,"score_gpt":0.372634473836331,"score_spread":0.1644856598671182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}