{"id":"W3043145743","doi":"10.1212/wnl.94.15_supplement.680","title":"Results of the Phase 3 SPI2 Study of MD1003 (high dose Pharmaceutical grade Biotin) in Progressive MS (680)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Biotin; Phase (matter); Medicine; Chemistry; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009283722,0.0001287434,0.0002319917,0.00002566913,0.00003286431,0.00000207542,0.0002423385,0.0001890847,0.000006098334],"category_scores_gemma":[0.0001593873,0.0000859404,0.00006522759,0.0001929808,0.0002763117,0.000001227863,0.0002581043,0.0002981614,0.000001579062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001535172,"about_ca_system_score_gemma":0.00002777878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000385156,"about_ca_topic_score_gemma":0.00003278596,"domain_scores_codex":[0.9987606,0.0002507244,0.0003489704,0.0003379351,0.0001059147,0.0001958053],"domain_scores_gemma":[0.9994858,0.00002708044,0.0001611284,0.0002301387,0.00004610145,0.00004976035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009965698,0.004674844,0.02407135,0.00008046995,0.0003419233,0.0001332048,0.001996535,0.0002062392,0.9538708,0.00007285232,0.002185086,0.002401036],"study_design_scores_gemma":[0.03121201,0.02493134,0.06954023,0.0000179401,0.0001754899,0.00004388153,0.0002902376,0.0002880465,0.8563843,0.00003735743,0.01675819,0.0003209232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940959,0.0005658149,0.000001202619,0.004456667,0.0002078197,0.0004342015,0.00002680256,0.000006000764,0.000205586],"genre_scores_gemma":[0.9987924,0.0001245151,0.00001558737,0.0009404552,0.00008843385,0.000008406166,0.000007770277,0.0000109766,0.00001145723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0974864,"threshold_uncertainty_score":0.3504548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721934365456633,"score_gpt":0.3205292510476123,"score_spread":0.293309907393046,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}