{"id":"W3043155723","doi":"10.1042/cs20190653","title":"Anthracycline-induced cardiomyopathy: cellular and molecular mechanisms","year":2020,"lang":"en","type":"review","venue":"Clinical Science","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Cardiotoxicity; Anthracycline; Cardiomyopathy; Dexrazoxane; Mechanism (biology); Intracellular; Cancer research; Cell biology; Pharmacology; Effector; Myocyte; Endoplasmic reticulum; Apoptosis; Biology; Heart failure; Medicine; Internal medicine; Chemotherapy; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002064771,0.0003828672,0.002349791,0.0001409732,0.0001588089,0.00008414582,0.0003901033,0.0005056052,0.00001980717],"category_scores_gemma":[0.00144103,0.0003033379,0.0008675291,0.001023247,0.0006582038,0.0001150627,0.0002353165,0.0009222319,0.00007908799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177003,"about_ca_system_score_gemma":0.001267732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005828649,"about_ca_topic_score_gemma":1.879185e-7,"domain_scores_codex":[0.9964973,0.0001913589,0.0009708336,0.001209885,0.000726429,0.0004042121],"domain_scores_gemma":[0.9978554,0.0002612246,0.0003446888,0.0006649001,0.0001309569,0.0007428876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006206898,0.00005816665,0.000001677139,0.00143387,0.00007388458,0.0002778202,0.00001749758,3.753048e-8,0.01550894,0.0006819861,0.00002559236,0.9819143],"study_design_scores_gemma":[0.0008597202,0.0006177489,0.00001449639,0.005154315,0.001566913,0.0003026338,0.00002539947,0.00008176755,0.02149936,0.0007113035,0.9685681,0.000598269],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002132742,0.9912832,0.002521332,0.0004583735,0.0007420173,0.001324563,0.00001176556,0.0001145886,0.0014114],"genre_scores_gemma":[0.01279892,0.9841959,0.001470788,0.0008673988,0.0005342464,0.00003036533,0.00002113389,0.00004669188,0.00003456528],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.981316,"threshold_uncertainty_score":0.9999419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09047067123169204,"score_gpt":0.4189177038509114,"score_spread":0.3284470326192194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}