{"id":"W3043183789","doi":"10.1128/mbio.00782-20","title":"Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2","year":2020,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Canada Research Chairs; International Graduate School in Molecular Medicine Ulm; U.S. Department of Health and Human Services","keywords":"Human immunodeficiency virus (HIV); Virology; Human leukocyte antigen; Computational biology; Biology; Genetics; Antigen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559398,0.0001979621,0.0001972837,0.0005102183,0.0002932364,0.0005276712,0.0002473404,0.0004376664,0.001298818],"category_scores_gemma":[0.0004091561,0.000149499,0.0001714469,0.0003313955,0.0003093451,0.0001986824,0.0004200039,0.0005490143,0.0002357684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003823012,"about_ca_system_score_gemma":0.0002643359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005518647,"about_ca_topic_score_gemma":0.0006843468,"domain_scores_codex":[0.9998266,0.00003290218,0.00001230919,0.00004801778,0.00003978951,0.00004039178],"domain_scores_gemma":[0.9998524,0.00002962547,0.00003566004,0.00002189549,0.00002153955,0.00003881496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003504166,0.00009204401,0.03061003,0.00006234706,0.00004391138,0.0008146761,0.0003152913,0.0005114359,0.9362271,0.002995829,0.0001487113,0.02782818],"study_design_scores_gemma":[0.0001047235,0.0009977131,0.6507645,0.00009857814,0.0001668894,0.01861542,0.0008332874,0.005424863,0.29339,0.002365863,0.02716441,0.0000736974],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960784,0.0009173363,0.0006490351,0.00008045782,0.00001318886,0.00001575143,0.00007348614,0.00001264686,0.002159667],"genre_scores_gemma":[0.997054,0.0007104923,0.0007581063,0.0001369201,0.0000172419,0.00001448632,0.0001521328,0.00001095552,0.001145716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001298818,"threshold_uncertainty_score":0.00434494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548769874050433,"score_gpt":0.2354261869888332,"score_spread":0.2199384882483289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}