{"id":"W3043205850","doi":"10.1101/2020.07.16.205922","title":"Targeted intragenic demethylation initiates chromatin rewiring for gene activation","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Cancer Institute; National Institutes of Health; Cancer Science Institute of Singapore, National University of Singapore; Ministry of Education, India; Medical Research Council; National Medical Research Council; National Research Foundation Singapore; National Research Foundation","keywords":"Chromatin; Genetics; Demethylation; Gene; Biology; ChIA-PET; Epigenetics; Computational biology; DNA demethylation; Chromatin remodeling; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002115866,0.000251678,0.0002305019,0.0002251025,0.0001876601,0.0002782386,0.000269149,0.0003036116,0.003725386],"category_scores_gemma":[0.0001982704,0.000218549,0.0002322083,0.00009614137,0.0002587,0.0002102115,0.000401152,0.0007857921,0.001197343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003002674,"about_ca_system_score_gemma":0.0001978013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002483802,"about_ca_topic_score_gemma":0.000566903,"domain_scores_codex":[0.9998484,0.00001534235,0.000007393213,0.00005548623,0.0000417663,0.00003170517],"domain_scores_gemma":[0.9998502,0.00003294477,0.00003634973,0.00003541696,0.00001202395,0.00003302086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003822942,0.000006391758,0.0001728022,0.00001969871,0.000002716717,0.00004110907,0.00001110348,0.00006769813,0.997038,0.0004278764,0.00009646237,0.002077888],"study_design_scores_gemma":[0.000005127483,0.00004667819,0.001303702,0.000002563929,0.000003178482,0.0001224207,0.000007490066,0.0005930695,0.9947233,0.000135084,0.003054519,0.000002832932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9001743,0.00228536,0.07520657,0.0004633427,0.000258373,0.0001164191,0.0008868087,0.001497796,0.01911111],"genre_scores_gemma":[0.9796723,0.000394605,0.01152237,0.0001073383,0.00002578707,0.00002911945,0.0003761001,0.0001259923,0.007746389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003725386,"threshold_uncertainty_score":0.01246262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02086299932355833,"score_gpt":0.2440417071315872,"score_spread":0.2231787078080288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}