{"id":"W3043250176","doi":"10.1016/j.lungcan.2020.07.014","title":"Mechanisms of osimertinib resistance and emerging treatment options","year":2020,"lang":"en","type":"review","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Princess Margaret Cancer Foundation","keywords":"Osimertinib; Medicine; Acquired resistance; Cancer research; Epidermal growth factor receptor; Internal medicine; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006277502,0.0007294863,0.001432926,0.001416966,0.0001707314,0.001177732,0.0007791507,0.001035096,0.004657842],"category_scores_gemma":[0.0009151236,0.0002267072,0.0006038613,0.001319459,0.0003599313,0.001141772,0.0005498336,0.001804829,0.0013265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007150706,"about_ca_system_score_gemma":0.001105891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001141427,"about_ca_topic_score_gemma":0.003233911,"domain_scores_codex":[0.9998388,0.0000295941,0.0000241722,0.00002947186,0.00005518728,0.00002272659],"domain_scores_gemma":[0.9997036,0.0001602899,0.00005335225,0.000005533914,0.00005420488,0.00002292344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001477597,0.00004685383,0.0001962635,0.01491372,0.0001222412,0.0001244473,0.00002925971,0.0005009743,0.0009174336,0.003639996,0.03244321,0.9469178],"study_design_scores_gemma":[0.00008360729,0.0001623339,0.001038442,0.007724661,0.0004078569,0.0009491736,0.00006166821,0.00027139,0.0003461293,0.003407169,0.985523,0.00002469577],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009297775,0.9984519,0.00007579048,0.0004213988,0.0001368615,0.000003319385,0.00002579787,0.000006314713,0.0007855739],"genre_scores_gemma":[0.0006198703,0.9982148,0.0001345331,0.000358982,0.0001794562,0.000005315864,0.00003943956,0.000001096158,0.0004464564],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004657842,"threshold_uncertainty_score":0.01558203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198790611506145,"score_gpt":0.4082846209134547,"score_spread":0.3762967147983932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}