{"id":"W3043250176","doi":"10.1016/j.lungcan.2020.07.014","title":"Mechanisms of osimertinib resistance and emerging treatment options","year":2020,"lang":"en","type":"review","venue":"Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Princess Margaret Cancer Foundation","keywords":"Osimertinib; Medicine; Acquired resistance; Cancer research; Epidermal growth factor receptor; Internal medicine; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002813372,0.0003037702,0.001279278,0.00009738249,0.00007338759,0.00001093565,0.00005211501,0.0001128854,0.0001981218],"category_scores_gemma":[0.0000108101,0.0002170564,0.0002806424,0.0002566939,0.00003879811,0.00003429082,0.00002460291,0.0001075668,0.000005265569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005707896,"about_ca_system_score_gemma":0.0007103464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001162212,"about_ca_topic_score_gemma":0.00006401341,"domain_scores_codex":[0.9988546,0.00003358628,0.0004019688,0.000376633,0.0001552305,0.0001780118],"domain_scores_gemma":[0.9992399,0.00004714012,0.000258605,0.0002571993,0.00005304545,0.0001441301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002953313,0.0001041521,0.00001511911,0.01720185,0.003039409,0.00004876733,0.0004215337,0.000001298511,0.000008280057,0.00339503,0.001567927,0.9741671],"study_design_scores_gemma":[0.0006934862,0.0001160934,0.00001170783,0.01154969,0.01246209,0.00001159638,0.00002816939,0.00001278383,0.00001446209,0.00006557743,0.9748719,0.0001623891],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000001799607,0.9953352,0.0002245036,0.0005078306,0.0002176418,0.001254893,0.0003446803,0.00004343294,0.002069997],"genre_scores_gemma":[0.00004399309,0.9916248,0.001415305,0.00006427299,0.0001179389,0.0008255472,0.0001300585,0.00005592154,0.005722219],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9740047,"threshold_uncertainty_score":0.8851305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198790611506145,"score_gpt":0.4082846209134547,"score_spread":0.3762967147983932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}