{"id":"W3043275684","doi":"10.1186/s13063-020-04577-8","title":"Protecting Frontline Health Care Workers from COVID-19 with Hydroxychloroquine Pre-exposure Prophylaxis: A structured summary of a study protocol for a randomised placebo-controlled multisite trial in Toronto, Canada","year":2020,"lang":"en","type":"letter","venue":"Trials","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Schwartz/Reisman Emergency Medicine Institute; Health Sciences Centre; Sunnybrook Health Science Centre; Sinai Health System; St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Arts and Humanities Research Council; National Research Council Canada; University of Toronto; Sunnybrook Research Institute; Department of Family and Community Medicine, University of Toronto; University Health Network Foundation; Department of Medicine, University of Toronto; McKnight Foundation","keywords":"Medicine; Hydroxychloroquine; Placebo; Pre-exposure prophylaxis; Randomized controlled trial; Clinical trial; Adverse effect; Seroconversion; Coronavirus disease 2019 (COVID-19); Internal medicine; Emergency medicine; Immunology; Disease; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01242009,0.003851836,0.006289091,0.0012756,0.002849399,0.002866252,0.002997469,0.005534241,0.03582951],"category_scores_gemma":[0.01062737,0.002243712,0.00463891,0.002066516,0.002289035,0.00129397,0.001002266,0.004071903,0.004900102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01138248,"about_ca_system_score_gemma":0.03329531,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05173296,"about_ca_topic_score_gemma":0.1461114,"domain_scores_codex":[0.993664,0.003220627,0.0006579305,0.0006138397,0.0006502561,0.001193269],"domain_scores_gemma":[0.9956839,0.0008374748,0.0008693847,0.0003855361,0.001019348,0.001204333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9095515,0.01240863,0.0007820119,0.01421909,0.001692188,0.0002623684,0.0004759862,0.002289471,0.003772944,0.002165367,0.01629686,0.0360835],"study_design_scores_gemma":[0.9498916,0.02597505,0.002933903,0.001720439,0.0007370365,0.00004077624,0.0000729639,0.0008774267,0.0004872455,0.000607353,0.01658781,0.00006830682],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.009354293,0.001173638,0.001438122,0.0004122089,0.0003901662,0.9832508,0.002115759,0.0001168316,0.001748129],"genre_scores_gemma":[0.0159036,0.001247995,0.00386987,0.0004525055,0.0001672502,0.9753835,0.0005203999,0.00001426525,0.002440766],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.948267,"threshold_uncertainty_score":0.1198617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08893039248075058,"score_gpt":0.4674426785187911,"score_spread":0.3785122860380405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}