{"id":"W3043275684","doi":"10.1186/s13063-020-04577-8","title":"Protecting Frontline Health Care Workers from COVID-19 with Hydroxychloroquine Pre-exposure Prophylaxis: A structured summary of a study protocol for a randomised placebo-controlled multisite trial in Toronto, Canada","year":2020,"lang":"en","type":"letter","venue":"Trials","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Schwartz/Reisman Emergency Medicine Institute; Health Sciences Centre; Sunnybrook Health Science Centre; Sinai Health System; St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Arts and Humanities Research Council; National Research Council Canada; University of Toronto; Sunnybrook Research Institute; Department of Family and Community Medicine, University of Toronto; University Health Network Foundation; Department of Medicine, University of Toronto; McKnight Foundation","keywords":"Medicine; Hydroxychloroquine; Placebo; Pre-exposure prophylaxis; Randomized controlled trial; Clinical trial; Adverse effect; Seroconversion; Coronavirus disease 2019 (COVID-19); Internal medicine; Emergency medicine; Immunology; Disease; Virus; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.008749787,0.001214126,0.01162833,0.0002734152,0.000296138,0.00006952308,0.0006455785,0.0007520749,0.0002111742],"category_scores_gemma":[0.2433785,0.0007862721,0.0009853091,0.0004435054,0.0001770186,0.0000919446,0.0002506486,0.003142746,3.94306e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.006288435,"about_ca_system_score_gemma":0.02699046,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8128442,"about_ca_topic_score_gemma":0.8483052,"domain_scores_codex":[0.9801097,0.007911545,0.006039177,0.001984634,0.002724444,0.001230522],"domain_scores_gemma":[0.9399252,0.05304806,0.004401275,0.001224997,0.0006550634,0.000745412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8740445,0.0004603062,0.0008978898,0.0100809,0.003732473,0.0006230793,0.004062687,0.000123752,0.00003032868,3.91523e-8,0.1045548,0.001389193],"study_design_scores_gemma":[0.920794,0.03174893,0.0001531131,0.002051466,0.0009552812,6.927982e-7,0.002083268,0.0001422223,0.00002065575,0.00001063985,0.04143413,0.0006056051],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.002158358,0.0005133486,0.0003095128,0.1297441,0.0002908972,0.8653121,0.001540988,0.0001183939,0.00001235513],"genre_scores_gemma":[0.01282071,0.000009022517,0.001502163,0.07382482,0.006023574,0.9047151,0.0006069818,0.0002107878,0.0002868256],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.2346287,"threshold_uncertainty_score":0.9994588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08893039248075058,"score_gpt":0.4674426785187911,"score_spread":0.3785122860380405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}