{"id":"W3043343007","doi":"10.1101/2020.07.15.191114","title":"Genetic variants for head size share genes and pathways with cancer","year":2020,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Pratt Foundation; National Institute on Aging; Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Kaiser Foundation Research Institute; Macquarie Group Foundation; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Erasmus Medisch Centrum; European Commission; University of Alabama at Birmingham; Australian Schizophrenia Research Bank; Bundesministerium für Bildung und Forschung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agence Nationale de la Recherche; University of Alabama; Ramsay Health Care; ZonMw; Northwestern University; Sylvia and Charles Viertel Charitable Foundation; University of Minnesota; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Biology; Gene; Wnt signaling pathway; Genetics; Brain size; PTEN; Human genome; Human brain; Genome; Signal transduction; Neuroscience; PI3K/AKT/mTOR pathway; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000342833,0.0004472327,0.0004633048,0.001260782,0.000400595,0.0004800173,0.0003709615,0.0005740328,0.00520141],"category_scores_gemma":[0.001712333,0.0001474665,0.0007758811,0.001917119,0.0005136012,0.0002006036,0.0004738049,0.0004537987,0.0003268578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440456,"about_ca_system_score_gemma":0.0002410084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003063609,"about_ca_topic_score_gemma":0.002581058,"domain_scores_codex":[0.9994975,0.0001049312,0.00003650294,0.0002023205,0.00009133236,0.00006738499],"domain_scores_gemma":[0.9986928,0.0006042197,0.0003736216,0.0001175653,0.00007867294,0.000133137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001547897,0.00006645907,0.8878455,0.0002678832,0.001883213,0.005044025,0.0001969451,0.0007627215,0.08463784,0.0008297554,0.0009375154,0.01598022],"study_design_scores_gemma":[0.00002687257,0.00008909991,0.9901744,0.00002638729,0.000513169,0.003320498,0.00007548266,0.0006688547,0.003208859,0.0005788679,0.00130309,0.00001447857],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909235,0.003607678,0.002074082,0.0002304275,0.00004062027,0.00001744562,0.001859891,0.00006102433,0.00118529],"genre_scores_gemma":[0.9974438,0.000604372,0.0006927825,0.00005603621,0.00002857528,0.00001166815,0.0007368589,0.00001435726,0.0004116372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00520141,"threshold_uncertainty_score":0.01740044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02185383630051834,"score_gpt":0.2419434538404893,"score_spread":0.2200896175399709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}