{"id":"W3043346807","doi":"10.1212/wnl.94.15_supplement.804","title":"Design of a Phase 2b Dose-finding Trial to Evaluate Safety and Efficacy of the CNS-penetrant BTK Inhibitor SAR442168 in Patients with Relapsing Forms of Multiple Sclerosis (804)","year":2020,"lang":"en","type":"article","venue":"Neurology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital; University of British Columbia","funders":"","keywords":"Penetrant (biochemical); Medicine; Multiple sclerosis; Bruton's tyrosine kinase; Pharmacology; Dermatology; Oncology; Internal medicine; Immunology; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006865108,0.001646269,0.001648361,0.0005877877,0.0006810738,0.001157176,0.0009955928,0.003447668,0.008850245],"category_scores_gemma":[0.003605262,0.0008543021,0.001633269,0.0003004745,0.0009350699,0.001291558,0.0006425339,0.003923003,0.001819853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000985548,"about_ca_system_score_gemma":0.003574393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003817433,"about_ca_topic_score_gemma":0.001069446,"domain_scores_codex":[0.9975643,0.001518813,0.0001083308,0.0002754536,0.0002004352,0.0003326663],"domain_scores_gemma":[0.9985828,0.0003357108,0.0002673457,0.0001471165,0.000135202,0.0005317494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8052381,0.05909463,0.002669482,0.001144491,0.001091131,0.0002742897,0.0001973361,0.00271903,0.03208177,0.002145753,0.006711935,0.08663213],"study_design_scores_gemma":[0.799715,0.188192,0.001506687,0.00006278578,0.0002421082,0.0001038474,0.00002235517,0.0008275372,0.002584792,0.001071565,0.005641831,0.00002934897],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.7002003,0.004192164,0.01834216,0.007471562,0.00275112,0.2452824,0.006738847,0.0004837889,0.01453773],"genre_scores_gemma":[0.6985019,0.002194216,0.05620971,0.01454768,0.001422513,0.2092369,0.002962837,0.000124247,0.01480007],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.008850245,"threshold_uncertainty_score":0.03630662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05628610320701249,"score_gpt":0.2833231516528835,"score_spread":0.227037048445871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}