{"id":"W3043357509","doi":"10.1002/jbmr.4132","title":"IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis","year":2020,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Research Grants Council, University Grants Committee; Harvard University","keywords":"Biology; Endocrinology; Internal medicine; Adipogenesis; Cell biology; Adipose tissue; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001557955,0.0003561529,0.0001797069,0.0001993378,0.0001567593,0.0002177522,0.0002513638,0.0002148738,0.002850597],"category_scores_gemma":[0.0000776448,0.0001252817,0.0003667185,0.00008944379,0.0002248782,0.0001091812,0.0001900669,0.0004486848,0.0004054785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002145526,"about_ca_system_score_gemma":0.0002269343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009222149,"about_ca_topic_score_gemma":0.001771251,"domain_scores_codex":[0.9998585,0.00001810132,0.00001758268,0.00002064155,0.00004995581,0.00003512743],"domain_scores_gemma":[0.9999076,0.00001455333,0.0000246327,0.00001242013,0.000009041955,0.00003164928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008595904,0.00002250942,0.0002016468,0.00003157742,0.000005124571,0.00001653287,0.000005909837,0.00002756652,0.9988739,0.00007177381,0.00003332233,0.0006241568],"study_design_scores_gemma":[0.00002676239,0.000406825,0.009383995,0.00001112166,0.00001982567,0.00011616,0.00003617897,0.0005117644,0.9871083,0.00003842349,0.002337478,0.000003373442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916908,0.002838458,0.001851869,0.00008346699,0.00003657262,0.00002203209,0.0002973947,0.00009469818,0.003084856],"genre_scores_gemma":[0.9909955,0.0008073021,0.001453336,0.00007853995,0.00000960965,0.00003204045,0.0003688253,0.00002159717,0.006233369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002850597,"threshold_uncertainty_score":0.009536207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05365741820730034,"score_gpt":0.3107401401557104,"score_spread":0.25708272194841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}