{"id":"W3043410578","doi":"10.1016/j.jve.2020.100004","title":"A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection","year":2020,"lang":"en","type":"article","venue":"Journal of Virus Eradication","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"U.S. Army Medical Research Acquisition Activity; National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; ViiV Healthcare; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Delaney AIDS Research Enterprise; National Institute of Neurological Disorders and Stroke; Medical Research Council; Gilead Sciences","keywords":"Vorinostat; Human immunodeficiency virus (HIV); Antiretroviral therapy; Medicine; Randomized controlled trial; Antiretroviral treatment; Virology; Internal medicine; Viral load; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002209903,0.0001543833,0.0005977169,0.000199944,0.00004123968,0.00001717698,0.00003187183,0.00004971903,0.0000551248],"category_scores_gemma":[0.00005449262,0.00009488881,0.0002261247,0.0001798902,0.00004617864,0.0002286146,0.000006589739,0.0001200463,0.000007573729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001700102,"about_ca_system_score_gemma":0.0001390678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001136917,"about_ca_topic_score_gemma":0.000002055809,"domain_scores_codex":[0.9986518,0.0001315132,0.0006781475,0.0001229841,0.0003078211,0.0001077542],"domain_scores_gemma":[0.998836,0.00005538508,0.0007727466,0.00008657204,0.0001454306,0.0001038935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9473802,0.0005714876,0.02738309,0.00003314864,0.001393833,0.00007273784,0.004621396,0.000009113232,0.008751918,0.00000831212,0.00002062429,0.009754079],"study_design_scores_gemma":[0.9294635,0.005642641,0.01547815,0.0002279721,0.000847669,0.0001303369,0.00005301,0.0002711435,0.04753069,0.00001114972,0.0002326756,0.0001110439],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957018,0.0001772122,0.001390608,0.001738123,0.00009577121,0.0007829182,0.000004234246,0.00001654791,0.00009274112],"genre_scores_gemma":[0.9957154,0.001676305,0.002010027,0.00007642551,0.0003253859,0.00004758255,0.00002052914,0.00001659726,0.0001116908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03877877,"threshold_uncertainty_score":0.3869453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03227883092817708,"score_gpt":0.3046008646436471,"score_spread":0.27232203371547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}