{"id":"W3043410578","doi":"10.1016/j.jve.2020.100004","title":"A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection","year":2020,"lang":"en","type":"article","venue":"Journal of Virus Eradication","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"U.S. Army Medical Research Acquisition Activity; National Center for Advancing Translational Sciences; National Cancer Institute; National Institutes of Health; ViiV Healthcare; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Delaney AIDS Research Enterprise; National Institute of Neurological Disorders and Stroke; Medical Research Council; Gilead Sciences","keywords":"Vorinostat; Human immunodeficiency virus (HIV); Antiretroviral therapy; Medicine; Randomized controlled trial; Antiretroviral treatment; Virology; Internal medicine; Viral load; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002739811,0.001639307,0.00301095,0.0005202214,0.0004885556,0.001320117,0.001113578,0.002162905,0.007161063],"category_scores_gemma":[0.003289107,0.0008568231,0.001664571,0.0003944242,0.001539101,0.001203604,0.0006530536,0.002614232,0.0008263132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007909201,"about_ca_system_score_gemma":0.001705196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009788414,"about_ca_topic_score_gemma":0.002097226,"domain_scores_codex":[0.9982677,0.001124124,0.000107682,0.0002118787,0.00008731274,0.0002012337],"domain_scores_gemma":[0.997391,0.0009261781,0.0005744729,0.000168756,0.0001244569,0.0008150238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9896113,0.005615184,0.0001741647,0.0001377837,0.000207346,0.0000141656,0.00001889426,0.00009156168,0.0006619124,0.00003701314,0.00008444137,0.003346253],"study_design_scores_gemma":[0.9451538,0.05397077,0.0003670896,0.000008850116,0.00009463957,0.000007615777,0.000008674586,0.0001625174,0.00009684859,0.00003881286,0.00008603482,0.000004238935],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901094,0.001332902,0.0004614755,0.0003524208,0.0006088451,0.005671389,0.0003324489,0.00006888058,0.001062261],"genre_scores_gemma":[0.9865675,0.001105094,0.001824656,0.0007225439,0.0006212214,0.006898703,0.0004694367,0.00001451661,0.001776367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007161063,"threshold_uncertainty_score":0.02395612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03227883092817708,"score_gpt":0.3046008646436471,"score_spread":0.27232203371547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}