{"id":"W3043431476","doi":"10.1016/j.cell.2020.07.012","title":"The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity","year":2020,"lang":"en","type":"article","venue":"Cell","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1640,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Canada","funders":"National Major Science and Technology Projects of China","keywords":"Infectivity; Biology; Antigenicity; Glycosylation; Virology; Antibody; Neutralizing antibody; Neutralization; Mutation; N-linked glycosylation; Virus; Genetics; Gene; Glycoprotein; Glycan","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002613296,0.0002680095,0.0001799945,0.0002134768,0.0001941284,0.0004073541,0.000238154,0.0003459621,0.002355624],"category_scores_gemma":[0.000471355,0.0001206294,0.0002675777,0.000150407,0.0002996341,0.0002951425,0.0002028268,0.0004491649,0.0003534538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003326262,"about_ca_system_score_gemma":0.0002560235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001804519,"about_ca_topic_score_gemma":0.001444787,"domain_scores_codex":[0.9997627,0.0000842396,0.00001877653,0.0000198387,0.00005134909,0.00006303613],"domain_scores_gemma":[0.9997293,0.0001386515,0.00002597386,0.00002206554,0.00003651906,0.00004744587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007366635,0.0001183008,0.001094143,0.00001456734,0.00001962936,0.0001529542,0.00003544493,0.000307441,0.9959396,0.0003197546,0.00008084816,0.001180729],"study_design_scores_gemma":[0.00005910819,0.00133306,0.02808365,0.000008722051,0.00005183911,0.0006735956,0.000142055,0.005038581,0.9627167,0.0002776795,0.001598854,0.00001606673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984616,0.0002119876,0.0002226009,0.00003892411,0.0000187094,0.000005440717,0.000108673,0.000006576027,0.0009254942],"genre_scores_gemma":[0.9988648,0.00008377692,0.0001594152,0.0000373823,0.000006419991,0.00000409897,0.0001856334,0.000008950071,0.0006495754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002355624,"threshold_uncertainty_score":0.00788039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05114901088527823,"score_gpt":0.3733379210858364,"score_spread":0.3221889102005582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}