{"id":"W3043454403","doi":"10.1016/j.jcf.2020.07.003","title":"CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation","year":2020,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Hospital for Sick Children; University of North Carolina at Chapel Hill; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Cystic fibrosis; Medicine; Mutation; Cystic fibrosis transmembrane conductance regulator; Internal medicine; Gastroenterology; Genetics; Gene; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001498824,0.0002462018,0.0004876902,0.0002224637,0.00033809,0.0001670988,0.0002360003,0.0009362209,0.002220658],"category_scores_gemma":[0.0003392611,0.00005293345,0.0003270413,0.0001443536,0.0002462777,0.000167368,0.0002122188,0.0007829969,0.0006811237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144493,"about_ca_system_score_gemma":0.0002389177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003996998,"about_ca_topic_score_gemma":0.0008676474,"domain_scores_codex":[0.9999267,0.00001416786,0.000007567673,0.00001395828,0.00002204801,0.00001566676],"domain_scores_gemma":[0.9999293,0.00001982738,0.0000130104,0.000003043918,0.000006562866,0.00002823366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.007914573,0.0007318006,0.01570536,0.0007536651,0.0003028309,0.09108195,0.0003790432,0.00119975,0.4376307,0.005468484,0.02843654,0.4103954],"study_design_scores_gemma":[0.005691573,0.0239522,0.08573147,0.001216237,0.001393377,0.3839803,0.0005374062,0.009571297,0.1582621,0.01239605,0.3170308,0.0002372293],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8955609,0.05677082,0.005950828,0.01532317,0.002246463,0.0001911745,0.000396898,0.0005981463,0.02296169],"genre_scores_gemma":[0.9874679,0.005145171,0.001948275,0.002030249,0.00037196,0.00003329795,0.0001947454,0.00003547436,0.002772941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002220658,"threshold_uncertainty_score":0.007428825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183632055211921,"score_gpt":0.3024334166768173,"score_spread":0.2805970961246981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}